Michael A. Matthay, M.D.

Critical care specialist

Additional Languages

French

Education

University of Pennsylvania 1973

Residencies

University of Colarado, Internal Medicine 1976

Fellowships

UCSF, Pulmonary Disease 1978

Selected Research and Publications

1. Agrawal A, Matthay MA, Kangelaris KN, Stein J, Chu JC, Imp BM, Cortez A, Abbott J, Liu KD, Calfee CS. Plasma angiopoietin-2 predicts the onset of acute lung injury in critically ill patients. Am J Respir Crit Care Med. 2013 Apr; 187(7):736-42.
2. Lee JW, Krasnodembskaya A, McKenna DH, Song Y, Abbott J, Matthay MA. Therapeutic effects of human mesenchymal stem cells in ex vivo human lungs injured with live bacteria. Am J Respir Crit Care Med. 2013 Apr; 187(7):751-60.
3. Thompson BT, Matthay MA. The Berlin Definition of ARDS versus Pathological Evidence of Diffuse Alveolar Damage. Am J Respir Crit Care Med. 2013 Apr; 187(7):675-7.
4. Katsumoto TR, Kudo M, Chen C, Sundaram A, Callahan EC, Zhu JW, Lin J, Rosen CE, Manz BN, Lee JW, Matthay MA, Huang X, Sheppard D, Weiss A. The phosphatase CD148 promotes airway hyperresponsiveness through SRC family kinases. J Clin Invest. 2013 May 1; 123(5):2037-48.
5. Seeley EJ, Barry SS, Narala S, Matthay MA, Wolters PJ. Noradrenergic Neurons Regulate Monocyte Trafficking and Mortality during Gram-Negative Peritonitis in Mice. J Immunol. 2013 May 1; 190(9):4717-24.
6. Seeley EJ, Rosenberg P, Matthay MA. Calcium flux and endothelial dysfunction during acute lung injury: a STIMulating target for therapy. J Clin Invest. 2013 Mar 1; 123(3):1015-8.
7. Cross LJ, O'Kane CM, McDowell C, Elborn JJ, Matthay MA, McAuley DF. Keratinocyte growth factor in acute lung injury to reduce pulmonary dysfunction - a randomised placebo-controlled trial (KARE): study protocol. Trials. 2013; 14:51.
8. Bhattacharya J, Matthay MA. Regulation and repair of the alveolar-capillary barrier in acute lung injury. Annu Rev Physiol. 2013 Feb 10; 75:593-615.
9. Su X, Feng X, Terrando N, Yan Y, Chawla A, Koch LG, Britton SL, Matthay MA, Maze M. Dysfunction of inflammation-resolving pathways is associated with exaggerated postoperative cognitive decline in a rat model of the metabolic syndrome. Mol Med. 2013; 18:1481-90.
10. Howard M, Roux J, Iles KE, Miyazawa B, Christiaans S, Anjum N, Dickinson DA, Goolaerts A, Matthay MA, Pittet JF. Activation of the heat shock response attenuates the interleukin 1ß-mediated inhibition of the amiloride-sensitive alveolar epithelial ion transport. Shock. 2013 Feb; 39(2):189-96.
11. Murphy EL, Kwaan N, Looney MR, Gajic O, Hubmayr RD, Gropper MA, Koenigsberg M, Wilson G, Matthay M, Bacchetti P, Toy P. Risk Factors and Outcomes in Transfusion-associated Circulatory Overload. Am J Med. 2013 Apr; 126(4):357.e29-38.
12. Schultz MJ, Juffermans NP, Matthay MA. From protective ventilation to super-protective ventilation for acute respiratory distress syndrome. Intensive Care Med. 2013 May; 39(5):963-5.
13. Bastarache JA, Matthay MA. Cecal ligation model of sepsis in mice: new insights*. Crit Care Med. 2013 Jan; 41(1):356-7.
14. Kallet RH, Matthay MA. Hyperoxic acute lung injury. Respir Care. 2013 Jan; 58(1):123-41.
15. Roux J, McNicholas CM, Carles M, Goolaerts A, Houseman BT, Dickinson DA, Iles KE, Ware LB, Matthay MA, Pittet JF. IL-8 inhibits cAMP-stimulated alveolar epithelial fluid transport via a GRK2/PI3K-dependent mechanism. FASEB J. 2013 Mar; 27(3):1095-106.
16. Komissarov AA, Stankowska D, Krupa A, Fudala R, Florova G, Florence J, Fol M, Allen TC, Idell S, Matthay MA, Kurdowska AK. Novel aspects of urokinase function in the injured lung: role of a2-macroglobulin. Am J Physiol Lung Cell Mol Physiol. 2012 Dec; 303(12):L1037-45.
17. Khush KK, Pawlikowska L, Menza RL, Goldstein BA, Hayden V, Nguyen J, Kim H, Poon A, Sapru A, Matthay MA, Kwok PY, Young WL, Baxter-Lowe LA, Zaroff JG. Beta-adrenergic receptor polymorphisms and cardiac graft function in potential organ donors. Am J Transplant. 2012 Dec; 12(12):3377-86.
18. Agrawal A, Zhuo H, Brady S, Levitt J, Steingrub J, Siegel MD, Soto G, Peterson MW, Chesnutt MS, Matthay MA, Liu KD. Pathogenetic and predictive value of biomarkers in patients with ALI and lower severity of illness: results from two clinical trials. Am J Physiol Lung Cell Mol Physiol. 2012 Oct 15; 303(8):L634-9.
19. Matthay MA, Ware LB, Zimmerman GA. The acute respiratory distress syndrome. J Clin Invest. 2012 Aug 1; 122(8):2731-40.
20. Zeyed YF, Bastarache JA, Matthay MA, Ware LB. The severity of shock is associated with impaired rates of net alveolar fluid clearance in clinical acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2012 Sep 15; 303(6):L550-5.

Publications are derived from MEDLINE/PubMed and provided by UCSF Profiles, a service of the Clinical & Translational Science Institute (CTSI) at UCSF. Researchers can make corrections and additions by logging on to UCSF Profiles.