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Robert Knowlton, M.D.


Dr. Robert Knowlton is a neurologist who specializes in diagnosing complex cases of epilepsy, such as those with no clear origin found using standard tests. In his clinical practice, Knowlton combines a variety of advanced diagnostic tests to pinpoint the source of seizures in the brain. He is especially interested in identifying patients who could successfully be treated with surgery and given a permanent option for a life free from seizures.

Knowlton's research focuses on neuroimaging and clinical decision-making in the surgical treatment of seizure disorders and brain tumors.


Epilepsy Center
400 Parnassus Ave., Eighth Floor
San Francisco, CA 94143
Phone: (415) 353-2437
Fax: (415) 353-2837

Hours: Monday to Friday
8 a.m. – 5 p.m.

Neurology Clinic
400 Parnassus Ave., Eighth Floor
San Francisco, CA 94143
Phone: (415) 353-2273
Fax: (415) 353-2898

Hours: Monday to Friday
8:30 a.m. – 4:30 p.m.

Conditions & Treatments

More about Robert Knowlton


Louisiana State University Health Sciences Center 1989


UCLA Medical Center 1993


UCSF Medical Center 1995

Selected Research and Publications

  1. Englot DJ, Nagarajan SS, Imber BS, Raygor KP, Honma SM, Mizuiri D, Mantle M, Knowlton RC, Kirsch HE, Chang EF. Epileptogenic zone localization using magnetoencephalography predicts seizure freedom in epilepsy surgery. Epilepsia. 2015 Apr 29.
  2. Englot DJ, Raygor KP, Molinaro AM, Garcia PA, Knowlton RC, Auguste KI, Chang EF. Factors associated with failed focal neocortical epilepsy surgery. Neurosurgery. 2014 Dec; 75(6):648-56.
  3. Esquenazi Y, Kalamangalam GP, Slater JD, Knowlton RC, Friedman E, Morris SA, Shetty A, Gowda A, Tandon N. Stereotactic laser ablation of epileptogenic periventricular nodular heterotopia. Epilepsy Res. 2014 Mar; 108(3):547-54.
  4. De novo mutations in epileptic encephalopathies. Nature. 2013 Sep 12; 501(7466):217-21.
  5. Ver Hoef LW, Paige AL, Riley KO, Cure J, Soltani M, Williams FB, Kennedy RE, Szaflarski JP, Knowlton RC. Evaluating hippocampal internal architecture on MRI: inter-rater reliability of a proposed scoring system. Epilepsy Res. 2013 Sep; 106(1-2):146-54.
  6. Ver Hoef LW, Williams FB, Kennedy RE, Szaflarski JP, Knowlton RC. Predictive value of hippocampal internal architecture asymmetry in temporal lobe epilepsy. Epilepsy Res. 2013 Sep; 106(1-2):155-63.
  7. Shain C, Ramgopal S, Fallil Z, Parulkar I, Alongi R, Knowlton R, Poduri A. Polymicrogyria-associated epilepsy: a multicenter phenotypic study from the Epilepsy Phenome/Genome Project. Epilepsia. 2013 Aug; 54(8):1368-75.
  8. Kim H, Kankirawatana P, Killen J, Harrison A, Oh A, Rozzelle C, Blount J, Knowlton R. Magnetic source imaging (MSI) in children with neocortical epilepsy: surgical outcome association with 3D post-resection analysis. Epilepsy Res. 2013 Sep; 106(1-2):164-72.
  9. Pisu M, Kratt P, Faught E, Martin RC, Kim Y, Clements K, Knowlton R, Funkhouser E, Richman JS. Geographic variation of epilepsy for older Americans: how close to the geographic variation of stroke? Epilepsia. 2012 Dec; 53(12):2186-93.
  10. Walker HC, Huang H, Gonzalez CL, Bryant JE, Killen J, Knowlton RC, Montgomery EB, Cutter GC, Yildirim A, Guthrie BL, Watts RL. Short latency activation of cortex by clinically effective thalamic brain stimulation for tremor. Mov Disord. 2012 Sep 15; 27(11):1404-12.
  11. Kim H, Harrison A, Kankirawatana P, Rozzelle C, Blount J, Torgerson C, Knowlton R. Major white matter fiber changes in medically intractable neocortical epilepsy in children: a diffusion tensor imaging study. Epilepsy Res. 2013 Feb; 103(2-3):211-20.
  12. Pisu M, Richman JS, Martin RC, Kim Y, Kratt P, Clements K, Funkhouser E, Knowlton R, Faught E. Diagnostic tests and neurology care for Medicare beneficiaries with seizures: differences across racial groups. Med Care. 2012 Aug; 50(8):730-6.
  13. Hutcheson NL, Reid MA, White DM, Kraguljac NV, Avsar KB, Bolding MS, Knowlton RC, den Hollander JA, Lahti AC. Multimodal analysis of the hippocampus in schizophrenia using proton magnetic resonance spectroscopy and functional magnetic resonance imaging. Schizophr Res. 2012 Sep; 140(1-3):136-42.
  14. Walker HC, Huang H, Gonzalez CL, Bryant JE, Killen J, Cutter GR, Knowlton RC, Montgomery EB, Guthrie BL, Watts RL. Short latency activation of cortex during clinically effective subthalamic deep brain stimulation for Parkinson's disease. Mov Disord. 2012 Jun; 27(7):864-73.
  15. Faught E, Richman J, Martin R, Funkhouser E, Foushee R, Kratt P, Kim Y, Clements K, Cohen N, Adoboe D, Knowlton R, Pisu M. Incidence and prevalence of epilepsy among older U.S. Medicare beneficiaries. Neurology. 2012 Feb 14; 78(7):448-53.
  16. Weller RE, Stoeckel LE, Milby JB, Bolding M, Twieg DB, Knowlton RC, Avison MJ, Ding Z. Smaller regional gray matter volume in homeless african american cocaine-dependent men: a preliminary report. Open Neuroimag J. 2011; 5:57-64.
  17. Bagic AI, Knowlton RC, Rose DF, Ebersole JS. American Clinical Magnetoencephalography Society Clinical Practice Guideline 1: recording and analysis of spontaneous cerebral activity. J Clin Neurophysiol. 2011 Aug; 28(4):348-54.
  18. Bagic AI, Knowlton RC, Rose DF, Ebersole JS. American Clinical Magnetoencephalography Society Clinical Practice Guideline 3: MEG-EEG reporting. J Clin Neurophysiol. 2011 Aug; 28(4):362-3.
  19. Kim H, Lee C, Knowlton R, Rozzelle C, Blount JP. Safety and utility of supplemental depth electrodes for localizing the ictal onset zone in pediatric neocortical epilepsy. J Neurosurg Pediatr. 2011 Jul; 8(1):49-56.
  20. Knowlton RC, Kar J, Miller S, Limdi N, Elgavish R, Gilliam FG, Riley K, Howell J, Kilgore M. Preference-based quality-of-life measures for neocortical epilepsy surgery. Epilepsia. 2011 May; 52(5):1018-20.

Publications are derived from MEDLINE/PubMed and provided by UCSF Profiles, a service of the Clinical & Translational Science Institute (CTSI) at UCSF. Researchers can make corrections and additions to their publications by logging on to UCSF Profiles.