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Robert C. Knowlton
4.9 out of 5 (112)
Robert C. Knowlton

Robert C. Knowlton, MD

Epilepsy Neurology

Epilepsy Center
400 Parnassus Ave., Eighth Floor,
San Francisco, CA 94143
(415) 353-2273
4.9 out of 5 (112)
Virtual visits available
4.9 out of 5 (112)
Virtual visits available
Epilepsy Center
400 Parnassus Ave., Eighth Floor,
San Francisco, CA 94143
(415) 353-2273

Dr. Robert Knowlton is a neurologist who specializes in diagnosing complex cases of epilepsy, such as those with no clear origin found using standard tests. In his clinical practice, Knowlton combines a variety of advanced diagnostic tests to pinpoint the source of seizures in the brain. He is especially interested in identifying patients who could successfully be treated with surgery and given a permanent option for a life free from seizures.

In addition to taking appointments at our Epilepsy Center in San Francisco, Knowlton sees patients in Marin County at our Neurosurgery Clinic in Greenbrae. All appointments should be made through the Epilepsy Center.

Knowlton's research focuses on neuroimaging and clinical decision making in the surgical treatment of seizure disorders and brain tumors.

  • Board Certifications

    American Board of Psychiatry and Neurology, Neurology

  • Fellowships

    UCSF, Epilepsy and Clinical Neurophysiology

  • Residencies

    University of California Los Angeles, Neurology

  • Internship

    Scottish Rite for Children, Flexible Or Transitional

  • Degree

    MD, LSU Health New Orleans

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"You can help many patients just by giving them information."

Meet Dr. Knowlton
My job is one big privilege. I learn more from my patients than from any other experience in my work or study. I can only hope that what my patients receive is close to the same.

Conditions I specialize in

Where I see patients (1)

    My reviews

    4.9

    Overall Experience
    112 Ratings
    About our process
    Aug 17, 2025
    This Dr was the first to explain my scans and that meant a lot to me. Very friendly and showed genuine care for me as a patient and as a person.
    Aug 07, 2025
    The kindest and most knowledgeable clinician I have ever seen for my chronic neurological conditions
    Jul 09, 2025
    The first doctor that listened....beyond grateful.
    Jul 07, 2025
    He is always caring and listens to my concerns.
    Jun 07, 2025
    Dr Knowlton is exceptional as a care provider.
    Jun 05, 2025
    Always attentive to my questions
    May 27, 2025
    Dr. Knowlton is so professional and has always great advice to give me for epilepsy. I refer him always.
    May 22, 2025
    I feel incredibly lucky to be in Dr Knowlton's care. He's a great listener, a kind man, honest about what he does and does not know, concerned about my condition.
    Apr 17, 2025
    He really listens to me
    Apr 16, 2025
    Dr. Knowlton knows what he's talking about and I feel very supported with his observations.
    Mar 28, 2025
    Dr. Knowlton is very helpful, informative and easy to speak with and has a great bedside manner.
    Mar 04, 2025
    Excellent, beyond a good doctor, a great human being!
    Mar 04, 2025
    Doc is Always excellent at his job
    Feb 12, 2025
    Wonderful experience
    Dec 23, 2024
    I would like to know when he is ordering a test. It's a good idea what he recommended. A likely much needed 24-hour EEG.
    Nov 27, 2024
    Truly exceptional.
    Nov 19, 2024
    Dr Knowlton is Wonderful
    Nov 13, 2024
    Ver y good listener and informative and caring
    Oct 31, 2024
    Not including how it was hard to go on the video call overall my appointment went well my Dr gave me a lot more info about what I needed and what I can do better to help my condition
    Oct 17, 2024
    Dr Knowlton is awesome.
    Sep 07, 2024
    I had a seizure at or just prior to Dr. Knowlton joining the video conference. He was able to determine I might be having a seizure based on visual cues. He then called my cell phone and left a message. After I recovered from the seizure I was able to rejoin the visit and found Dr. Knowlton still on the video visit. I am very happy with the level of care provided during this incident.
    Sep 04, 2024
    Dr Knowlton is the very best provider we are lucky to be part of his care.
    Aug 07, 2024
    The doctor was incredibly kind with an excellent demeanor and extremely knowledgeable and helpful and empathetic.
    Aug 06, 2024
    Of course I would recommend it
    Jun 10, 2024
    Thank you Dr. Knowlton. I appreciate you!
    Jun 03, 2024
    Dr Knowlton is exceptional in all aspects of providing care during the appointment.
    May 23, 2024
    I found Dr. Knowlton to be very engaging. My appointment felt more conversational, which was nice. Dr. Knowlton provided helpful information and conceded there are a lot of unknowns. I appreciated his candor. I also appreciated his respect of my viewpoint.
    Apr 25, 2024
    So incredibly thankful Dr Knowelton is my provider
    Apr 19, 2024
    Dr Knowlton has been wonderfully informative and sympathetic. I am very thankful to be in his care.
    Apr 12, 2024
    Excellent!!!
    Mar 23, 2024
    He is awesome!!!!
    Dec 24, 2023
    D'r Knowlton and Staff are awesome
    Nov 24, 2023
    Dr. Knowlton is exceptional.
    Nov 14, 2023
    The doctor said he would notify me of my next appointment but I haven't heard from him

    Selected research

    See all research
    Decorative Caduceus

    A Phase 1/2 Study of NRTX-1001 Neuronal Cell Therapy in Drug-Resistant Bilateral Mesial Tempora...

    Recruiting

    Decorative Caduceus

    FIH Study of NRTX-1001 Neural Cell Therapy in Drug-Resistant Unilateral Mesial Temporal Lobe Ep...

    The primary endpoint of the study is the frequency of serious or severe AEs over the period of 1 year after administration, comparing all subjects treated with NRTX-1001 (Phase 1 + Phase 2) with all subjects who receive sham treat...

    Recruiting

    My work

    "Rebooting" the brain of a patient with epilepsy

    Kimberly began having debilitating seizures and anxiety while overseas. Care from Dr. Knowlton and colleagues finally brought her condition under control.

    Contact me

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