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Tom Lue, M.D.


Dr. Tom Lue is an internationally recognized expert in the treatment of male sexual dysfunction at UCSF Medical Center. In 1983, he was one of the first urologists in the country to offer penile injection for erectile dysfunction. His research team proved that a new class of compound enhances erection in animals, which provided the scientific basis for three medications — Viagra, Levitra and Cialis, the most popular treatments for erectile dysfunction. Lue and his associates also developed the first animal model to study Peyronie's disease and introduced pentoxifylline for treatment.

Lue is vice chair of urology, medical director of the Knuppe Molecular Urology Laboratory and a professor of urology at UCSF. He graduated with highest honors from the Kaohsiung Medical College in Taiwan, completed urologic training at Downstate Medical Center in Brooklyn, N.Y. and was awarded the Valentine Fellowship from the New York Academy of Medicine to study the neurophysiology of the genitourinary tract at UCSF. He has won numerous awards, including the American Urological Association's Gold Cystoscope award and American Foundation of Urologic Disease's "Most Innovative Research Award." Lue has authored or co-authored more than 380 publications and 12 books on male sexual dysfunction.


Urology Practice
400 Parnassus Ave., Sixth Floor, Suite A610
San Francisco, CA 94143
Phone: (415) 353-2200
Fax: (415) 353-2641

Hours: Monday to Friday
8 a.m. – 5 p.m.

Conditions & Treatments

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Kaohsiung Medical College 1972


SUNY Downstate Medical Center, Urology 1981


UCSF Medical Center, Urology

Selected Research and Publications

  1. Wang L, Sanford MT, Xin Z, Lin G, Lue TF. Role of Schwann cells in the regeneration of penile and peripheral nerves. Asian J Androl. 2015 Sep-Oct; 17(5):776-82.
  2. Alwaal A, Hussein AA, Lin CS, Lue TF. Prospects of stem cell treatment in benign urological diseases. Korean J Urol. 2015 Apr; 56(4):257-65.
  3. Wang L, Zhang X, Wang G, Visweswariah SS, Lin G, Xin Z, Lue TF, Lin CS. Lobe-specific Expression of Phosphodiesterase 5 in Rat Prostate. Urology. 2015 Mar; 85(3):703.e7-703.e13.
  4. Alwaal A, Wang L, Zaid UB, Lin G, Lue TF. Case series of lipid accumulation in the human corpus cavernosum. Medicine (Baltimore). 2015 Feb; 94(6):e550.
  5. Lin G, Alwaal A, Zhang X, Wang J, Wang L, Li H, Wang G, Ning H, Lin CS, Xin Z, Lue TF. Presence of stem/progenitor cells in the rat penis. Stem Cells Dev. 2015 Jan 15; 24(2):264-70.
  6. Alwaal A, Hussein AA, Zaid UB, Lue TF. Management of Peyronie's Disease after Collagenase (Xiaflex:®). Curr Drug Targets. 2015; 16(5):484-94.
  7. Lin G, Alwaal A, Sun F, Zhang H, Li H, Wang L, Wang G, Ning H, Banie L, Lin CS, Lue TF. Estrogen Attenuates TGF-ß1 Induced Elastogenesis in Rat Urethral Smooth Muscle Cells by Inhibiting Smad Response Elements. J Urol. 2015 Jun; 193(6):2131-7.
  8. Alwaal A, Zaid UB, Lin CS, Lue TF. Stem cell treatment of erectile dysfunction. Adv Drug Deliv Rev. 2015 Mar; 82-83:137-44.
  9. Wang J, Huang V, Ye L, Bárcena A, Lin G, Lue TF, Li LC. Identification of Small Activating RNAs that Enhance Endogenous OCT4 Expression in Human Mesenchymal Stem Cells. Stem Cells Dev. 2015 Feb 1; 24(3):345-53.
  10. Lin G, Li H, Zhang X, Wang J, Zaid U, Sanford MT, Tu V, Wu A, Wang L, Tian F, Kotanides H, Krishnan V, Wang G, Ning H, Banie L, Lin CS, Deng GG, Lue TF. Novel therapeutic approach for neurogenic erectile dysfunction: effect of neurotrophic tyrosine kinase receptor type 1 monoclonal antibody. Eur Urol. 2015 Apr; 67(4):716-26.
  11. Zaid UB, Alwaal A, Zhang X, Lue TF. Surgical management of Peyronie's disease. Curr Urol Rep. 2014 Oct; 15(10):446.
  12. Ning H, Lei HE, Xu YD, Guan RL, Venstrom JM, Lin G, Lue TF, Xin Z, Lin CS. Conversion of adipose-derived stem cells into natural killer-like cells with anti-tumor activities in nude mice. PLoS One. 2014; 9(8):e106246.
  13. Ferretti L, Fandel TM, Qiu X, Zhang H, Orabi H, Wu AK, Banie L, Wang G, Lin G, Lin CS, Lue TF. Tunica albuginea allograft: a new model of LaPeyronie's disease with penile curvature and subtunical ossification. Asian J Androl. 2014 Jul-Aug; 16(4):592-6.
  14. Li X, Fang D, Cooperberg MR, Whitson JM, Lue TF, Zhou L, Shinohara K. Long-term follow-up of International Prostate Symptom Score (IPSS) in men following prostate brachytherapy. World J Urol. 2014 Aug; 32(4):1061-6.
  15. Lin CS, Xin Z, Dai J, Huang YC, Lue TF. Stem-cell therapy for erectile dysfunction. Expert Opin Biol Ther. 2013 Nov; 13(11):1585-97.
  16. Albersen M, Berkers J, Dekoninck P, Deprest J, Lue TF, Hedlund P, Lin CS, Bivalacqua TJ, Van Poppel H, De Ridder D, Van der Aa F. Expression of a Distinct Set of Chemokine Receptors in Adipose Tissue-Derived Stem Cells is Responsible for In Vitro Migration Toward Chemokines Appearing in the Major Pelvic Ganglion Following Cavernous Nerve Injury. Sex Med. 2013 Aug; 1(1):3-15.
  17. Song WD, Yuan YM, Cui WS, Wu AK, Zhu YC, Liu J, Wang L, Bai GY, Peng J, Zhang ZC, Gao B, Guo YL, Lue TF, Xin ZC. Penile prosthesis implantation in Chinese patients with severe erectile dysfunction: 10-year experience. Asian J Androl. 2013 Sep; 15(5):658-61.
  18. Lin CS, Xin ZC, Dai J, Lue TF. Commonly used mesenchymal stem cell markers and tracking labels: Limitations and challenges. Histol Histopathol. 2013 Sep; 28(9):1109-16.
  19. Hakky TS, Ferguson D, Spiess PE, Bradley P, Lue TF, Carrion RE. Three-dimensional mapping and comparative analysis of the distal human corpus cavernosum and the inflatable penile prosthesis. Asian J Androl. 2013 Jul; 15(4):567-70.
  20. Khurana A, Nejadnik H, Chapelin F, Lenkov O, Gawande R, Lee S, Gupta SN, Aflakian N, Derugin N, Messing S, Lin G, Lue TF, Pisani L, Daldrup-Link HE. Ferumoxytol: a new, clinically applicable label for stem-cell tracking in arthritic joints with MRI. Nanomedicine (Lond). 2013 Dec; 8(12):1969-83.

Publications are derived from MEDLINE/PubMed and provided by UCSF Profiles, a service of the Clinical & Translational Science Institute (CTSI) at UCSF. Researchers can make corrections and additions to their publications by logging on to UCSF Profiles.