Drugs Reported to Cause Priapism

In one-third of the cases, the cause of priapism is unknown. The remaining cases are caused by an associated condition, including sickle cell disease, pelvic tumors, pelvic infections, leukemia, genital trauma or spinal cord trauma. A variety of medications or recreational drugs also can lead to priapism.


  • Bupropion
  • Trazodone
  • Fluoxetine
  • Sertraline and lithium


  • Clozapine

Antianxiety Agents

  • Hydroxyzine


  • Chlorpromazine

Alpha-adrenergic Blocker

  • Prazosin


  • Gonadotropin-releasing hormone (in hypogonadal men)
  • Testosterone


  • Heparin
  • Coumadin

Recreational Drugs

  • Cocaine
  • Alcohol


Reviewed by health care specialists at UCSF Medical Center.

This information is for educational purposes only and is not intended to replace the advice of your doctor or health care provider. We encourage you to discuss with your doctor any questions or concerns you may have.

Related Information

UCSF Clinics & Centers

Urology Practice
400 Parnassus Ave., Sixth Floor, Suite A610
San Francisco, CA 94143
Phone: (415) 353-2200
Fax: (415) 353-2641

Condition Information