Jean Nakamura, MD

Radiation oncologist

Dr. Jean Nakamura is a radiation oncologist who specializes in the treatment of brain and spinal cord tumors using techniques such as intensity modulated radiotherapy, Gamma Knife and Cyberknife radiosurgery in children and adults. In addition to caring for patients, she researches radiosurgery techniques and their use in treating complex diseases involving the brain and spinal cord. She's particularly interested in tumors located at the base of the skull, which are challenging to treat because they're close to structures critical to nervous system function.

Nakamura has received many awards including the Radiological Society of North America Roentgen Award for Resident Research and the Basic Research Fellowship Award from the American Brain Tumor Association. She is a member of the American College of Radiology, Radiological Society of North America, American Society of Therapeutic Radiology and Oncology, Society for Neuro-Oncology and American Association for Cancer Research. She earned a medical degree at the University of Chicago Pritzker School of Medicine and completed an internship in Internal Medicine at the University of Chicago. She then came to UCSF for a residency in radiation oncology, followed by a fellowship in neuro-oncology research. She is an associate professor at UCSF.


Brain Tumor Center
400 Parnassus Ave., Eighth Floor
San Francisco, CA 94143
Phone: (415) 353-2966
Fax: (415) 353-2167

Hours: Monday to Friday, 8 a.m. - 5 p.m.

Radiation Oncology at Mount Zion
1600 Divisadero St., Basement Level
San Francisco, CA 94143-1708
Main Phone: (415) 353-7175
New Patient Appointments: (415) 353-9807
Fax: (415) 353-9884

Hours: Monday to Friday
7 a.m. – 6 p.m.

Radiation Oncology at Parnassus
505 Parnassus Ave, Room L-75
San Francisco, CA 94143-0226
Main Phone: (415) 353-7175
New Patient Appointments: (415) 353-8335
Fax: (415) 353-7281

Hours: Monday to Friday
8 a.m. – 4:30 p.m.

Conditions & Treatments

More about Jean Nakamura


University of Chicago Pritzker School of Medicine 1998


UCSF Medical Center, Radiation Oncology 2003

Selected Research and Publications

  1. Davidson PR, Sherborne AL, Taylor B, Nakamura AO, Nakamura JL. A pooled mutational analysis identifies ionizing radiation-associated mutational signatures conserved between mouse and human malignancies. Sci Rep. 2017 Aug 09; 7(1):7645.
  2. Imber BS, Kanungo I, Braunstein S, Barani IJ, Fogh SE, Nakamura JL, Berger MS, Chang EF, Molinaro AM, Cabrera JR, McDermott MW, Sneed PK, Aghi MK. Indications and Efficacy of Gamma Knife Stereotactic Radiosurgery for Recurrent Glioblastoma: 2 Decades of Institutional Experience. Neurosurgery. 2017 Jan 01; 80(1):129-139.
  3. Garcia MA, Lazar A, Duriseti S, Raleigh DR, Hess CP, Fogh SE, Barani IJ, Nakamura JL, Larson DA, Theodosopoulos P, McDermott M, Sneed PK, Braunstein S. Discovery of additional brain metastases on the day of stereotactic radiosurgery: risk factors and outcomes. J Neurosurg. 2017 Jun; 126(6):1756-1763.
  4. Kaprealian T, Raleigh DR, Sneed PK, Nabavizadeh N, Nakamura JL, McDermott MW. Parameters influencing local control of meningiomas treated with radiosurgery. J Neurooncol. 2016 Jun; 128(2):357-64.
  5. Held M, Cremers F, Sneed PK, Braunstein S, Fogh SE, Nakamura J, Barani I, Perez-Andujar A, Pouliot J, Morin O. Assessment of image quality and dose calculation accuracy on kV CBCT, MV CBCT, and MV CT images for urgent palliative radiotherapy treatments. J Appl Clin Med Phys. 2016 03 08; 17(2):279-290.
  6. Sherborne AL, Davidson PR, Yu K, Nakamura AO, Rashid M, Nakamura JL. Mutational Analysis of Ionizing Radiation Induced Neoplasms. Cell Rep. 2015 Sep 22; 12(11):1915-26.
  7. McGuinness CM, Gottschalk AR, Lessard E, Nakamura JL, Pinnaduwage D, Pouliot J, Sims C, Descovich M. Investigating the clinical advantages of a robotic linac equipped with a multileaf collimator in the treatment of brain and prostate cancer patients. J Appl Clin Med Phys. 2015 Sep; 16(5):284-295.
  8. Mroue R, Huang B, Braunstein S, Firestone AJ, Nakamura JL. Correction: Monoallelic Loss of the Imprinted Gene Grb10 Promotes Tumor Formation in Irradiated Nf1+/- Mice. PLoS Genet. 2015 Jun; 11(6):e1005327.
  9. Mroue R, Huang B, Braunstein S, Firestone AJ, Nakamura JL. Monoallelic loss of the imprinted gene Grb10 promotes tumor formation in irradiated Nf1+/- mice. PLoS Genet. 2015 May; 11(5):e1005235.
  10. Sneed PK, Mendez J, Vemer-van den Hoek JG, Seymour ZA, Ma L, Molinaro AM, Fogh SE, Nakamura JL, McDermott MW. Adverse radiation effect after stereotactic radiosurgery for brain metastases: incidence, time course, and risk factors. J Neurosurg. 2015 Aug; 123(2):373-86.
  11. Seymour ZA, Fogh SE, Westcott SK, Braunstein S, Larson DA, Barani IJ, Nakamura J, Sneed PK. Interval From Imaging to Treatment Delivery in the Radiation Surgery Age: How Long Is Too Long? Int J Radiat Oncol Biol Phys. 2015 Sep 01; 93(1):126-32.
  12. Li N, Maly DJ, Chanthery YH, Sirkis DW, Nakamura JL, Berger MS, James CD, Shokat KM, Weiss WA, Persson AI. Radiotherapy followed by aurora kinase inhibition targets tumor-propagating cells in human glioblastoma. Mol Cancer Ther. 2015 Feb; 14(2):419-28.
  13. Ma L, Sahgal A, Larson DA, Pinnaduwage D, Fogh S, Barani I, Nakamura J, McDermott M, Sneed P. Impact of millimeter-level margins on peripheral normal brain sparing for gamma knife radiosurgery. Int J Radiat Oncol Biol Phys. 2014 May 01; 89(1):206-13.
  14. Fouse SD, Nakamura JL, James CD, Chang S, Costello JF. Response of primary glioblastoma cells to therapy is patient specific and independent of cancer stem cell phenotype. Neuro Oncol. 2014 Mar; 16(3):361-71.
  15. Braunstein S, Nakamura JL. Radiotherapy-induced malignancies: review of clinical features, pathobiology, and evolving approaches for mitigating risk. Front Oncol. 2013; 3:73.
  16. Wahl M, Hwang A, Nakamura J, Barani I, Fogh S, Sneed P, McDermott M, Sahgal A, Ma L. Individual beam sharpening improves composite dose fall-off near a target for non-isocentric cyberknife radiosurgery. Technol Cancer Res Treat. 2013 Aug; 12(4):341-8.
  17. Fogh S, Ma L, Gupta N, Sahgal A, Nakamura JL, Barani I, Sneed PK, McDermott M, Larson DA. High-precision volume-staged Gamma Knife surgery and equivalent hypofractionation dose schedules for treating large arteriovenous malformations. J Neurosurg. 2012 Dec; 117 Suppl:115-9.
  18. Choi G, Huang B, Pinarbasi E, Braunstein SE, Horvai AE, Kogan S, Bhatia S, Faddegon B, Nakamura JL. Genetically mediated Nf1 loss in mice promotes diverse radiation-induced tumors modeling second malignant neoplasms. Cancer Res. 2012 Dec 15; 72(24):6425-34.
  19. Caballero JA, Sneed PK, Lamborn KR, Ma L, Denduluri S, Nakamura JL, Barani IJ, McDermott MW. Prognostic factors for survival in patients treated with stereotactic radiosurgery for recurrent brain metastases after prior whole brain radiotherapy. Int J Radiat Oncol Biol Phys. 2012 May 01; 83(1):303-9.
  20. Ma L, Lee L, Barani I, Hwang A, Fogh S, Nakamura J, McDermott M, Sneed P, Larson DA, Sahgal A. Shot sequencing based on biological equivalent dose considerations for multiple isocenter Gamma Knife radiosurgery. Phys Med Biol. 2011 Nov 21; 56(22):7247-56.

Publications are derived from MEDLINE/PubMed and provided by UCSF Profiles, a service of the Clinical & Translational Science Institute (CTSI) at UCSF. Researchers can make corrections and additions to their publications by logging on to UCSF Profiles.