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Bladder biopsy

Definition

Bladder biopsy is a procedure in which small pieces of tissue are removed from the bladder. The tissue is tested under a microscope.

Alternative Names

Biopsy - bladder

How the Test is Performed

A bladder biopsy can be done as part of a cystoscopy. Cystoscopy is a procedure that is done to see the inside of the bladder using a thin lighted tube called a cystoscope. A small piece of tissue or the entire abnormal area is removed. The tissue is sent to the lab to be tested if:

  • Abnormalities of the bladder are found during this exam
  • A tumor is seen

How to Prepare for the Test

You must sign an informed consent form before you have a bladder biopsy. In most cases, you are asked to urinate just before the procedure. You may also be asked to take an antibiotic before the procedure.

For infants and children, the preparation you can provide for this test depends on your child's age, previous experiences, and level of trust. For general information regarding how you can prepare your child, see the following topics:

  • Infant test or procedure preparation (birth to 1 year)
  • Toddler test or procedure preparation (1 to 3 years)
  • Preschooler test or procedure preparation (3 to 6 years)
  • School age test or procedure preparation (6 to 12 years)
  • Adolescent test or procedure preparation (12 to 18 years)

How the Test will Feel

You may have a slight discomfort as the cystoscope is passed through your urethra into your bladder. You will feel discomfort that is similar to a strong urge to urinate when the fluid has filled your bladder.

You may feel a pinch during the biopsy. There may be a burning sensation when the blood vessels are sealed to stop bleeding (cauterized).

After the cystoscope is removed, your urethra may be sore. You may feel a burning sensation during urination for a day or two. There may be blood in the urine. In most cases, this will go away on its own.

In some cases, the biopsy needs to be taken from a large area. In that case, you may need general anesthesia or sedation before the procedure.

Why the Test is Performed

This test is most often done to check for cancer of the bladder or urethra.

Normal Results

The bladder wall is smooth. The bladder is of a normal size, shape, and position. There are no blockages, growths, or stones.

What Abnormal Results Mean

The presence of cancer cells indicates bladder cancer. The type of cancer can be determined from the biopsy sample.

Other abnormalities may include:

  • Bladder diverticula
  • Cysts
  • Inflammation
  • Infection
  • Ulcers

Risks

There is some risk for urinary tract infection (UTI).

There is a slight risk for excessive bleeding. There may be a rupture of the bladder wall with the cystoscope or during biopsy.

There is also a risk that the biopsy will fail to detect a serious condition.

Considerations

You will likely have a small amount of blood in your urine shortly after this procedure. If the bleeding continues after you urinate, contact your health care provider.

Also contact your provider if:

  • You have pain, chills, or a fever
  • You are producing less urine than usual (oliguria)
  • You cannot urinate despite a strong urge to do so

References

Cundiff GW, Bent AE. Cystourethroscopy. In: Baggish MS, Karram MM, eds. Atlas of Pelvic Anatomy and Gynecologic Surgery. 5th ed. Philadelphia, PA: Elsevier; 2021:chap 120.

Duty BD, Conlin MJ. Principles of urologic endoscopy. In: Partin AW, Dmochowski RR, Kavoussi LR, Peters CA, eds. Campbell-Walsh-Wein Urology. 12th ed. Philadelphia, PA: Elsevier; 2021:chap 13.

National Institute of Diabetes and Digestive and Kidney Diseases website. Cystoscopy and ureteroscopy. www.niddk.nih.gov/health-information/diagnostic-tests/cystoscopy-ureteroscopy. Updated July 2021. Accessed August 23, 2022.

Taylor JM, Smith TG, Coburn M. Urologic surgery. In: Townsend CM Jr, Beauchamp RD, Evers BM, Mattox KL, eds. Sabiston Textbook of Surgery. 21st ed. Philadelphia, PA: Elsevier; 2022:chap 74.

Review Date: 04/10/2022

The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed physician should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. Copyright ©2019 A.D.A.M., Inc., as modified by University of California San Francisco. Any duplication or distribution of the information contained herein is strictly prohibited.

Information developed by A.D.A.M., Inc. regarding tests and test results may not directly correspond with information provided by UCSF Health. Please discuss with your doctor any questions or concerns you may have.

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