Quantitative Bence-Jones protein test
This test measures the level of abnormal proteins called Bence-Jones proteins in the urine.
Immunoglobulin light chains - urine; Urine Bence-Jones protein
How the Test is Performed
The sample is sent to the lab. There are many methods used to detect Bence-Jones proteins. One method, called
How the Test will Feel
The test involves only normal urination, and there is no discomfort.
Why the Test is Performed
Bence-Jones proteins are a part of regular
Your provider may order this test:
- To diagnose conditions that lead to protein in the urine
- If you have a lot of protein in your urine
- If you have signs of a blood cancer called
A normal result means no Bence-Jones proteins are found in your urine.
What Abnormal Results Mean
Bence-Jones proteins are rarely found in urine. If they are, it is usually associated with
An abnormal result may also be due to:
- An abnormal buildup of proteins in tissues and organs (
- Blood cancer called
chronic lymphocytic leukemia
- Lymph system cancer (lymphoma)
- Buildup in the blood of a protein called M-protein (monoclonal gammopathy of unknown significance; MGUS)
- Chronic renal failure
There are no risks with this test.
Chernecky CC, Berger BJ. Protein electrophoresis - urine. In: Chernecky CC, Berger BJ, eds. Laboratory Tests and Diagnostic Procedures. 6th ed. St Louis, MO: Elsevier Saunders; 2013:920-922.
Riley RS, McPherson RA. Basic examination of urine. In: McPherson RA, Pincus MR, eds. Henry's Clinical Diagnosis and Management by Laboratory Methods. 24th ed. Philadelphia, PA: Elsevier; 2022:chap 29.
Rajkumar SV, Dispenzieri A. Multiple myeloma and related disorders. In: Niederhuber JE, Armitage JO, Kastan MB, Doroshow JH, Tepper JE, eds. Abeloff's Clinical Oncology. 6th ed. Philadelphia, PA: Elsevier; 2020:chap 101.
Review Date: 04/29/2022
The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed physician should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. Copyright ©2019 A.D.A.M., Inc., as modified by University of California San Francisco. Any duplication or distribution of the information contained herein is strictly prohibited.
Information developed by A.D.A.M., Inc. regarding tests and test results may not directly correspond with information provided by UCSF Health. Please discuss with your doctor any questions or concerns you may have.