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James L. Rubenstein



Dr. James Rubenstein is a hematologist-oncologist, or a specialist in blood disorders. He has particular expertise in treating patients with neurologic complications from cancer, including patients with non-Hodgkin's lymphoma involving the brain (called central nervous system lymphoma). He also specializes in patients with cancer that has spread to the brain from other parts of the body.

In his research, Rubenstein investigates immunologic tools to improve tumor response to chemotherapy and radiation treatment, and to minimize toxicity from treatment. He is also interested in developing tumor biomarkers to diagnose brain tumors.

Rubenstein earned his medical degree at Weill Cornell Medicine and completed a residency in internal medicine at Stanford Medicine. He earned a doctorate in molecular and cellular neurosciences at the Rockefeller University. He completed a fellowship in hematology and oncology at UCSF, which included training in neuro-oncology.

Rubenstein has won research awards from the Leukemia & Lymphoma Society and the National Cancer Institute. He is a member of the American Society of Hematology, American Society of Clinical Oncology and American Association for Cancer Research.

  • Education

    Cornell University Medical College, 1992

  • Residencies

    Stanford, Internal Medicine, 1995

  • Fellowships

    UCSF Cancer Research Institute, Hematology/Oncology, 1997

  • Board Certifications

    Medical Oncology, American Board of Internal Medicine

  • Academic Title


  • Languages


Where I see patients (1)

    My reviews


    Overall Experience
    144 Ratings
    About our process
    Nov 11, 2023
    I was at ease conversing with the provider.Very accommodating .
    Nov 07, 2023
    Dr Rubenstein is the best. I believed he saved my life in 2020 with his expert care analysis and treatment.
    Oct 15, 2023
    Dr .Rubenstein and all his assistants are perfect. I can not ask for better.
    Oct 07, 2023
    I LOVE Dr Rubenstein UCSF is very lucky to have him.
    Aug 30, 2023
    Feeling satisfied every time II have conversation with my care provider.
    Aug 09, 2023
    Doctor is easy to talk to.
    Aug 04, 2023
    I really appreciate the fact that Dr Rubenstein is concerned about my health as a whole. He encourages me to keep walking regularly and to watch my blood pressure. He listens to my health concerns and what's going on in my life. It helps me to have a more positive outlook in managing my health.
    Jul 25, 2023
    Dr. Rubenstein is personable kind and thorough. He listens to his patients and offers advice and options for you to consider.
    Jul 20, 2023
    The provider was attentive to my concerns.
    Jul 11, 2023
    Dr Rubenstein Is always responsive to my questions and concerns and addresses them in a caring way.
    Jun 29, 2023
    Care provider explained well answer my question assured me that I will be taken care of.
    Jun 09, 2023
    Wording maybe less multiple emphasis on death from safe procedures for anxious patient...
    May 30, 2023
    Able to talk to care giver with ease.
    May 09, 2023
    Dr Rubenstein is very thorough in coordinating my treatment in and out of the hospital. He always takes time to check in with all of us on the calls. My family and I feel very fortunate that he is my doctor. His expertise with PCNS lymphoma and commitment to an aggressive treatment for me inspires our confidence and trust.
    Apr 14, 2023
    Mar 31, 2023
    Dr Rubenstein is such wonderful Dr. I can't ask more.
    Mar 21, 2023
    Wonderful and insightful experience
    Feb 02, 2023
    I simply admire my care provider James Rubinstein for working with me for over a decade during my battle with my brain cancer. He Is my hero and I would recommend anyone his services.
    Jan 21, 2023
    Nov 10, 2022
    Dr Rubenstein is one of the best. An expert at his height still listens to the needs of patients and family.
    Nov 03, 2022
    Dr Rubenstein is most wonderful MD I ever met.
    Sep 14, 2022
    Dr. Rubenstein was very meticulous about explaining the time that I go back to taking my medication after I was diagnosed with COVID-19.
    Aug 19, 2022
    Dr. Rubenstein continues to be honest truthful and helpful while I've been under his care. He is easy to talks to and treats me with respect.
    Mar 20, 2022
    We had a very productive discussion. We talked about a plan to watch for recurrences of the lymphoma and what treatment options we might consider should that happen. That included Dr Rubenstein being sensitive to the fact that I will never have imaging at UCSF again after a horrible experience at the Parnassus MRI. (Now I go to NorCal which has superior patient care.) We also talked about what I should do if I believed that I had been exposed to COVID. Finally we discussed all of the vitamins and supplements I take to stay healthy. We covered a lot and I appreciate that Dr Rubenstein was able to approach my health from multiple perspectives.
    Mar 12, 2022
    I love everyone
    Feb 12, 2022
    Dr. Rubenstein is incredible. He has taken great care of my health. It's rare to find a doctor that combines such personal touches and care for a patient as a person with outstanding quality of medical care. I highly recommend becoming his patient!
    Decorative Caduceus

    Tafasitamab Plus Lenalidomide in Relapsed CNS Lymphoma

    Toxicities will be classified using the NCI Common Terminology Criteria for Adverse Events (CTCAE) version 5.0. The DLT will be based on the tolerability observed during the first cycle. In order for a patient to be assessed for D...


    Decorative Caduceus

    Feasibility of Acquiring Hyperpolarized Imaging in Patients With Primary CNS Lymphoma

    The Common Terminology Criteria for Adverse Events (NCI CTCAE version 5.0) will be used to classify and graded any adverse events that occur after the participant has received the hyperpolarized 13C injection.