What is TIL therapy?
Tumor-infiltrating lymphocyte (TIL) therapy is a type of personalized immunotherapy for solid cancers, meaning it deploys cells from the patient's own immune system to fight their cancer. Lymphocytes (a kind of white blood cell) play an important role in the immune system, helping fight off infections and diseases. TILs are lymphocytes that have learned to recognize and destroy cancer cells, and can be found inside a tumor.
TIL therapy involves surgery to remove the patient's tumor. The tumor tissue is then put through a special process to isolate the TILs and multiply them into billions of cancer-fighting cells. They are then infused back into the patient.
Lifileucel (brand name Amtagvi) is the first TIL therapy approved by the Food and Drug Administration (FDA). Lifileucel has shown promising results in patients whose metastatic melanoma (melanoma that has spread from its original site) has worsened after treatment with other drugs, including other immunotherapies and molecularly targeted therapies. In clinical trials (studies with human volunteers), some patients have improved or even achieved long-term remission after receiving lifileucel.
UCSF is one of only a few hospitals in the region offering TIL therapy.
Our approach to TIL therapy
UCSF has been administering cancer immunotherapies, such as TIL therapy, since 2011. As part of our commitment to comprehensive cancer care, we have a special clinic devoted to these treatments. In addition to patient care, we are dedicated to discovering better treatments through research. Interested patients may have opportunities to participate in clinical trials evaluating promising immunotherapies. Learn about the process and potential benefits of participating in a clinical trial.