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Edward Chang, M.D.


Dr. Edward Chang is a neurosurgeon with expertise in treating intractable epilepsy, trigeminal neuralgia, movement disorders and brain tumors in adults. He specializes in advanced brain mapping methods, including awake speech and motor mapping, to safely perform surgery in the brain. He also has extensive experience with implantable devices for neuromodulation.

Chang's research focuses upon the brain mechanisms for human speech, movement and cognition. He is faculty in the Center for Integrative Neuroscience and the Neuroscience and Bioengineering graduate programs. He co-directs the Center for Neural Engineering & Prostheses at UC Berkeley and UCSF, which brings together engineering, neuroscience, neurology and neurosurgery to develop state-of-the-art biomedical devices to restore function for patients with neurological disabilities such as paralysis and speech disorders. He earned a medical degree and completed neurosurgery residency training at UCSF. Chang is an associate professor of neurological surgery and physiology at UCSF.

Read a Q&A with Chang about surgical treatments for epilepsy.


Epilepsy Center
400 Parnassus Ave., Eighth Floor
San Francisco, CA 94143
Phone: (415) 353-2437
Fax: (415) 353-2837

Hours: Monday to Friday
8 a.m. – 5 p.m.

Neurosurgery Clinic
400 Parnassus Ave., Eighth Floor
San Francisco, CA 94143
Phone: (415) 353-7500
Fax: (415) 353-2889

Hours: Monday to Friday
8 a.m. – 4:30 p.m.

Trigeminal Neuralgia Clinic
400 Parnassus Ave., Eighth Floor
San Francisco, CA 94143
Medical Management:
(415) 353-2892
Surgical Management:
(415) 353-2241
Medical Management Fax:
(415) 353-2898
Surgical Management Fax :
(415) 353-2889

Hours: Monday to Friday
8 a.m. – 5 p.m.

Conditions & Treatments

  • Gamma Knife
  • Glossopharyngeal Neuralgia
  • Hemifacial Spasm

More about Edward Chang


UCSF School of Medicine 2004


UCSF Medical Center, Neurosurgery 2010

Selected Research and Publications

  1. Englot DJ, Knowlton RC, Chang EF, Kirsch HE, Nagarajan SS. 106 Functional Network Analysis in Surgical Epilepsy Patients Using Magnetoencephalography. Neurosurgery. 2015 Aug; 62 Suppl 1:198.
  2. Voytek B, Kayser AS, Badre D, Fegen D, Chang EF, Crone NE, Parvizi J, Knight RT, D'Esposito M. Oscillatory dynamics coordinating human frontal networks in support of goal maintenance. Nat Neurosci. 2015 Jul 27.
  3. Wilson SM, Lam D, Babiak MC, Perry DW, Shih T, Hess CP, Berger MS, Chang EF. Transient aphasias after left hemisphere resective surgery. J Neurosurg. 2015 Sep; 123(3):581-93.
  4. Cibelli ES, Leonard MK, Johnson K, Chang EF. The influence of lexical statistics on temporal lobe cortical dynamics during spoken word listening. Brain Lang. 2015 Jun 10; 147:66-75.
  5. Chang EF, Englot DJ, Vadera S. Minimally invasive surgical approaches for temporal lobe epilepsy. Epilepsy Behav. 2015 May 23; 47:24-33.
  6. Englot DJ, Hinkley LB, Kort NS, Imber BS, Mizuiri D, Honma SM, Findlay AM, Garrett C, Cheung PL, Mantle M, Tarapore PE, Knowlton RC, Chang EF, Kirsch HE, Nagarajan SS. Global and regional functional connectivity maps of neural oscillations in focal epilepsy. Brain. 2015 May 16.
  7. Houde JF, Chang EF. The cortical computations underlying feedback control in vocal production. Curr Opin Neurobiol. 2015 May 15; 33:174-181.
  8. Breshears JD, Molinaro AM, Chang EF. A probabilistic map of the human ventral sensorimotor cortex using electrical stimulation. J Neurosurg. 2015 May 15; 1-10.
  9. Leonard MK, Bouchard KE, Tang C, Chang EF. Dynamic encoding of speech sequence probability in human temporal cortex. J Neurosci. 2015 May 6; 35(18):7203-14.
  10. Englot DJ, Nagarajan SS, Imber BS, Raygor KP, Honma SM, Mizuiri D, Mantle M, Knowlton RC, Kirsch HE, Chang EF. Epileptogenic zone localization using magnetoencephalography predicts seizure freedom in epilepsy surgery. Epilepsia. 2015 Apr 29.
  11. Chang EF. Towards large-scale, human-based, mesoscopic neurotechnologies. Neuron. 2015 Apr 8; 86(1):68-78.
  12. Meng L, Weston SD, Chang EF, Gelb AW. Awake craniotomy in a patient with ejection fraction of 10%: considerations of cerebrovascular and cardiovascular physiology. J Clin Anesth. 2015 Feb 10.
  13. Rolston JD, Ouyang D, Englot DJ, Wang DD, Chang EF. National trends and complication rates for invasive extraoperative electrocorticography in the USA. J Clin Neurosci. 2015 May; 22(5):823-7.
  14. Tempel ZJ, Chivukula S, Monaco EA, Bowden G, Kano H, Niranjan A, Chang EF, Sneed PK, Kaufmann AM, Sheehan J, Mathieu D, Lunsford LD. The results of a third Gamma Knife procedure for recurrent trigeminal neuralgia. J Neurosurg. 2015 Jan; 122(1):169-79.
  15. Cheng JS, Salinas R, Molinaro A, Chang EF, Kunwar S, Blevins L, Aghi MK. A predictive algorithm for evaluating elevated serum prolactin in patients with a sellar mass. J Clin Neurosci. 2015 Jan; 22(1):155-60.
  16. Englot DJ, Raygor KP, Molinaro AM, Garcia PA, Knowlton RC, Auguste KI, Chang EF. Factors associated with failed focal neocortical epilepsy surgery. Neurosurgery. 2014 Dec; 75(6):648-56.
  17. Chang EF, Raygor KP, Berger MS. Contemporary model of language organization: an overview for neurosurgeons. J Neurosurg. 2015 Feb; 122(2):250-61.
  18. Wang DD, Benkli B, Auguste KI, Garcia PA, Sullivan J, Barkovich AJ, Chang EF, Tihan T. Unilateral holohemispheric central nervous system lesions associated with medically refractory epilepsy in the pediatric population: a retrospective series of hemimegalencephaly and Rasmussen's encephalitis. J Neurosurg Pediatr. 2014 Dec; 14(6):573-84.
  19. Bouchard KE, Chang EF. Control of spoken vowel acoustics and the influence of phonetic context in human speech sensorimotor cortex. J Neurosci. 2014 Sep 17; 34(38):12662-77.
  20. Englot DJ, Han SJ, Rolston JD, Ivan ME, Kuperman RA, Chang EF, Gupta N, Sullivan JE, Auguste KI. Epilepsy surgery failure in children: a quantitative and qualitative analysis. J Neurosurg Pediatr. 2014 Oct; 14(4):386-95.

Publications are derived from MEDLINE/PubMed and provided by UCSF Profiles, a service of the Clinical & Translational Science Institute (CTSI) at UCSF. Researchers can make corrections and additions to their publications by logging on to UCSF Profiles.