Edward Chang, MD

Neurosurgeon

Dr. Edward Chang is a neurosurgeon with expertise in treating intractable epilepsy, trigeminal neuralgia, movement disorders and brain tumors in adults. He specializes in advanced brain mapping methods, including awake speech and motor mapping, to safely perform surgery in the brain. He also has extensive experience with implantable devices for neuromodulation.

Chang's research focuses upon the brain mechanisms for human speech, movement and cognition. He is faculty in the Center for Integrative Neuroscience and the Neuroscience and Bioengineering graduate programs. He co-directs the Center for Neural Engineering & Prostheses at UC Berkeley and UCSF, which brings together engineering, neuroscience, neurology and neurosurgery to develop state-of-the-art biomedical devices to restore function for patients with neurological disabilities such as paralysis and speech disorders. He earned a medical degree and completed neurosurgery residency training at UCSF. Chang is a professor of neurological surgery and physiology at UCSF.

Read a Q&A with Chang about surgical treatments for epilepsy.

Clinics

Epilepsy Center
400 Parnassus Ave., Eighth Floor
San Francisco, CA 94143
Phone: (415) 353-2437
Fax: (415) 353-2837

Hours: Monday to Friday
8 a.m. – 5 p.m.

Movement Disorder and Neuromodulation Center
1635 Divisadero St., Suite 520
San Francisco, CA 94115
Neurology: (415) 353-2311
Neurosurgery: (415) 353-2071
Fax: (415) 353-9060

Hours: Monday to Friday
8 a.m. – 5 p.m.

Neurosurgery Clinic
400 Parnassus Ave., Eighth Floor
San Francisco, CA 94143
Phone: (415) 353-7500
Fax: (415) 353-2889

Hours: Monday to Friday
8 a.m. – 4:30 p.m.

Trigeminal Neuralgia Clinic
400 Parnassus Ave., Eighth Floor
San Francisco, CA 94143
Phone: (415) 353-2892
Fax: (415) 353-2898

Hours: Monday to Friday
8 a.m. – 5 p.m.

Conditions & Treatments

Board Certification

Neurological Surgery, American Board of Neurological Surgery

Academic Title

Professor

More about Edward Chang

Education

UCSF School of Medicine 2004

Residencies

UCSF Medical Center, Neurosurgery 2010

Selected Research and Publications

  1. Muller L, Rolston JD, Fox NP, Knowlton R, Rao VR, Chang EF. Direct electrical stimulation of human cortex evokes high gamma activity that predicts conscious somatosensory perception. J Neural Eng. 2018 Apr; 15(2):026015.
  2. Shirvalkar P, Veuthey TL, Dawes HE, Chang EF. Closed-Loop Deep Brain Stimulation for Refractory Chronic Pain. Front Comput Neurosci. 2018; 12:18.
  3. Sorrells SF, Paredes MF, Cebrian-Silla A, Sandoval K, Qi D, Kelley KW, James D, Mayer S, Chang J, Auguste KI, Chang EF, Gutierrez AJ, Kriegstein AR, Mathern GW, Oldham MC, Huang EJ, Garcia-Verdugo JM, Yang Z, Alvarez-Buylla A. Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults. Nature. 2018 Mar 15; 555(7696):377-381.
  4. Perry A, Stiso J, Chang EF, Lin JJ, Parvizi J, Knight RT. Mirroring in the Human Brain: Deciphering the Spatial-Temporal Patterns of the Human Mirror Neuron System. Cereb Cortex. 2018 Mar 01; 28(3):1039-1048.
  5. Chan AY, Rolston JD, Rao VR, Chang EF. Effect of neurostimulation on cognition and mood in refractory epilepsy. Epilepsia Open. 2018 Mar; 3(1):18-29.
  6. Conant DF, Bouchard KE, Leonard MK, Chang EF. Human Sensorimotor Cortex Control of Directly Measured Vocal Tract Movements during Vowel Production. J Neurosci. 2018 Mar 21; 38(12):2955-2966.
  7. Khoshkhoo S, Leonard MK, Mesgarani N, Chang EF. Neural correlates of sine-wave speech intelligibility in human frontal and temporal cortex. Brain Lang. 2018 Jan 31.
  8. Moses DA, Leonard M, Chang EF. Real-time classification of auditory sentences using evoked cortical activity in humans. J Neural Eng. 2018 Jan 30.
  9. Baud MO, Kleen JK, Mirro EA, Andrechak JC, King-Stephens D, Chang EF, Rao VR. Multi-day rhythms modulate seizure risk in epilepsy. Nat Commun. 2018 01 08; 9(1):88.
  10. Wang Q, Hu B, Hu X, Kim H, Squatrito M, Scarpace L, deCarvalho AC, Lyu S, Li P, Li Y, Barthel F, Cho HJ, Lin YH, Satani N, Martinez-Ledesma E, Zheng S, Chang E, Gabriel Sauvé CE, Olar A, Lan ZD, Finocchiaro G, Phillips JJ, Berger MS, Gabrusiewicz KR, Wang G, Eskilsson E, Hu J, Mikkelsen T, DePinho RA, Muller F, Heimberger AB, Sulman EP, Nam DH, Verhaak RGW. Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment. Cancer Cell. 2018 Jan 08; 33(1):152.
  11. Winkler EA, Birk H, Burkhardt JK, Chen X, Yue JK, Guo D, Rutledge WC, Lasker GF, Partow C, Tihan T, Chang EF, Su H, Kim H, Walcott BP, Lawton MT. Reductions in brain pericytes are associated with arteriovenous malformation vascular instability. J Neurosurg. 2018 Jan 05; 1-11.
  12. Wang DD, Deng H, Hervey-Jumper SL, Molinaro AA, Chang EF, Berger MS. Seizure Outcome After Surgical Resection of Insular Glioma. Neurosurgery. 2017 Nov 08.
  13. Hamilton LS, Chang DL, Lee MB, Chang EF. Semi-automated Anatomical Labeling and Inter-subject Warping of High-Density Intracranial Recording Electrodes in Electrocorticography. Front Neuroinform. 2017; 11:62.
  14. Rolston JD, Chang EF. Critical Language Areas Show Increased Functional Connectivity in Human Cortex. Cereb Cortex. 2017 Oct 17; 1-8.
  15. Baud MO, Kleen JK, Anumanchipalli GK, Hamilton LS, Tan YL, Knowlton R, Chang EF. Unsupervised Learning of Spatiotemporal Interictal Discharges in Focal Epilepsy. Neurosurgery. 2017 Oct 10.
  16. González Otárula KA, Tan YL, Dubeau F, Correa JA, Chang E, Hall JA, Knowlton RC, Kobayashi E. Psychogenic nonepileptic seizures in patients with surgically treated temporal lobe epilepsy: Presurgical and de novo postsurgical occurrence. Epilepsy Behav. 2017 Oct; 75:252-255.
  17. Chiong W, Leonard MK, Chang EF. Neurosurgical Patients as Human Research Subjects: Ethical Considerations in Intracranial Electrophysiology Research. Neurosurgery. 2017 Jul 22.
  18. Wang Q, Hu B, Hu X, Kim H, Squatrito M, Scarpace L, deCarvalho AC, Lyu S, Li P, Li Y, Barthel F, Cho HJ, Lin YH, Satani N, Martinez-Ledesma E, Zheng S, Chang E, Sauvé CG, Olar A, Lan ZD, Finocchiaro G, Phillips JJ, Berger MS, Gabrusiewicz KR, Wang G, Eskilsson E, Hu J, Mikkelsen T, DePinho RA, Muller F, Heimberger AB, Sulman EP, Nam DH, Verhaak RGW. Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment. Cancer Cell. 2017 07 10; 32(1):42-56.e6.
  19. Dynamic tracking of non-stationarity in human ECoG activity. Conf Proc IEEE Eng Med Biol Soc. 2017 07; 2017:1660-1663.
  20. Bouchard KE, Bujan AF, Chang EF, Sommer FT. Sparse coding of ECoG signals identifies interpretable components for speech control in human sensorimotor cortex. Conf Proc IEEE Eng Med Biol Soc. 2017 07; 2017:3636-3639.

Publications are derived from MEDLINE/PubMed and provided by UCSF Profiles, a service of the Clinical & Translational Science Institute (CTSI) at UCSF. Researchers can make corrections and additions to their publications by logging on to UCSF Profiles.