Edward Chang, MD


Dr. Edward Chang is a neurosurgeon with expertise in treating intractable epilepsy, trigeminal neuralgia, movement disorders and brain tumors in adults. He specializes in advanced brain mapping methods, including awake speech and motor mapping, to safely perform surgery in the brain. He also has extensive experience with implantable devices for neuromodulation.

Chang's research focuses upon the brain mechanisms for human speech, movement and cognition. He is faculty in the Center for Integrative Neuroscience and the Neuroscience and Bioengineering graduate programs. He co-directs the Center for Neural Engineering & Prostheses at UC Berkeley and UCSF, which brings together engineering, neuroscience, neurology and neurosurgery to develop state-of-the-art biomedical devices to restore function for patients with neurological disabilities such as paralysis and speech disorders. He earned a medical degree and completed neurosurgery residency training at UCSF. Chang is a professor of neurological surgery and physiology at UCSF.

Read a Q&A with Chang about surgical treatments for epilepsy.


Epilepsy Center
400 Parnassus Ave., Eighth Floor
San Francisco, CA 94143
Phone: (415) 353-2437
Fax: (415) 353-2837

Hours: Monday to Friday
8 a.m. – 5 p.m.

Movement Disorder and Neuromodulation Center
1635 Divisadero St., Suite 520
San Francisco, CA 94115
Neurology: (415) 353-2311
Neurosurgery: (415) 353-2071
Fax: (415) 353-9060

Hours: Monday to Friday
8 a.m. – 5 p.m.

Neurosurgery Clinic
400 Parnassus Ave., Eighth Floor
San Francisco, CA 94143
Phone: (415) 353-7500
Fax: (415) 353-2889

Hours: Monday to Friday
8 a.m. – 4:30 p.m.

Trigeminal Neuralgia Clinic
400 Parnassus Ave., Eighth Floor
San Francisco, CA 94143
Phone: (415) 353-2892
Fax: (415) 353-2898

Hours: Monday to Friday
8 a.m. – 5 p.m.

Conditions & Treatments

Board Certification

Neurological Surgery

More about Edward Chang


UCSF School of Medicine 2004


UCSF Medical Center, Neurosurgery 2010

Selected Research and Publications

  1. Baud MO, Kleen JK, Mirro EA, Andrechak JC, King-Stephens D, Chang EF, Rao VR. Multi-day rhythms modulate seizure risk in epilepsy. Nat Commun. 2018 Jan 08; 9(1):88.
  2. Baud MO, Kleen JK, Anumanchipalli GK, Hamilton LS, Tan YL, Knowlton R, Chang EF. Unsupervised Learning of Spatiotemporal Interictal Discharges in Focal Epilepsy. Neurosurgery. 2017 Oct 10.
  3. González Otárula KA, Tan YL, Dubeau F, Correa JA, Chang E, Hall JA, Knowlton RC, Kobayashi E. Psychogenic nonepileptic seizures in patients with surgically treated temporal lobe epilepsy: Presurgical and de novo postsurgical occurrence. Epilepsy Behav. 2017 Oct; 75:252-255.
  4. Chiong W, Leonard MK, Chang EF. Neurosurgical Patients as Human Research Subjects: Ethical Considerations in Intracranial Electrophysiology Research. Neurosurgery. 2017 Jul 22.
  5. Wang Q, Hu B, Hu X, Kim H, Squatrito M, Scarpace L, deCarvalho AC, Lyu S, Li P, Li Y, Barthel F, Cho HJ, Lin YH, Satani N, Martinez-Ledesma E, Zheng S, Chang E, Sauvé CG, Olar A, Lan ZD, Finocchiaro G, Phillips JJ, Berger MS, Gabrusiewicz KR, Wang G, Eskilsson E, Hu J, Mikkelsen T, DePinho RA, Muller F, Heimberger AB, Sulman EP, Nam DH, Verhaak RGW. Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment. Cancer Cell. 2017 Jul 10; 32(1):42-56.e6.
  6. Rolston JD, Deng H, Wang DD, Englot DJ, Chang EF. Multiple Subpial Transections for Medically Refractory Epilepsy: A Disaggregated Review of Patient-Level Data. Neurosurgery. 2017 Jun 20.
  7. Murugesan S, Bouchard K, Chang E, Dougherty M, Hamann B, Weber GH. Multi-scale visual analysis of time-varying electrocorticography data via clustering of brain regions. BMC Bioinformatics. 2017 Jun 06; 18(Suppl 6):236.
  8. Nahum M, Van Vleet TM, Sohal VS, Mirzabekov JJ, Rao VR, Wallace DL, Lee MB, Dawes H, Stark-Inbar A, Jordan JT, Biagianti B, Merzenich M, Chang EF. Immediate Mood Scaler: Tracking Symptoms of Depression and Anxiety Using a Novel Mobile Mood Scale. JMIR Mhealth Uhealth. 2017 Apr 12; 5(4):e44.
  9. Rao VR, Leonard MK, Kleen JK, Lucas BA, Mirro EA, Chang EF. Chronic ambulatory electrocorticography from human speech cortex. Neuroimage. 2017 Jun; 153:273-282.
  10. Wang DD, Raygor KP, Cage TA, Ward MM, Westcott S, Barbaro NM, Chang EF. Prospective comparison of long-term pain relief rates after first-time microvascular decompression and stereotactic radiosurgery for trigeminal neuralgia. J Neurosurg. 2017 Feb 24; 1-10.
  11. Perry A, Stiso J, Chang EF, Lin JJ, Parvizi J, Knight RT. Mirroring in the Human Brain: Deciphering the Spatial-Temporal Patterns of the Human Mirror Neuron System. Cereb Cortex. 2017 Jan 30.
  12. Weiss SA, Asadi-Pooya AA, Vangala S, Moy S, Wyeth DH, Orosz I, Gibbs M, Schrader L, Lerner J, Cheng CK, Chang E, Rajaraman R, Keselman I, Churchman P, Bower-Baca C, Numis AL, Ho MG, Rao L, Bhat A, Suski J, Asadollahi M, Ambrose T, Fernandez A, Nei M, Skidmore C, Mintzer S, Eliashiv DS, Mathern GW, Nuwer MR, Sperling M, Engel J, Stern JM. AR2, a novel automatic artifact reduction software method for ictal EEG interpretation: Validation and comparison of performance with commercially available software. F1000Res. 2017; 6:30.
  13. Imber BS, Kanungo I, Braunstein S, Barani IJ, Fogh SE, Nakamura JL, Berger MS, Chang EF, Molinaro AM, Cabrera JR, McDermott MW, Sneed PK, Aghi MK. Indications and Efficacy of Gamma Knife Stereotactic Radiosurgery for Recurrent Glioblastoma: 2 Decades of Institutional Experience. Neurosurgery. 2017 Jan 01; 80(1):129-139.
  14. Leonard MK, Baud MO, Sjerps MJ, Chang EF. Perceptual restoration of masked speech in human cortex. Nat Commun. 2016 Dec 20; 7:13619.
  15. Rolston JD, Han SJ, Chang EF. Systemic inaccuracies in the National Surgical Quality Improvement Program database: Implications for accuracy and validity for neurosurgery outcomes research. J Clin Neurosci. 2017 Mar; 37:44-47.
  16. Simonyan K, Ackermann H, Chang EF, Greenlee JD. New Developments in Understanding the Complexity of Human Speech Production. J Neurosci. 2016 Nov 09; 36(45):11440-11448.
  17. Rübel O, Dougherty M, Denes P, Conant D, Chang EF, Bouchard K. Methods for Specifying Scientific Data Standards and Modeling Relationships with Applications to Neuroscience. Front Neuroinform. 2016; 10:48.
  18. Godlove J, Gulati T, Dichter B, Chang E, Ganguly K. Muscle synergies after stroke are correlated with perilesional high gamma. Ann Clin Transl Neurol. 2016 Dec; 3(12):956-961.
  19. Englot DJ, Rolston JD, Wright CW, Hassnain KH, Chang EF. Rates and Predictors of Seizure Freedom With Vagus Nerve Stimulation for Intractable Epilepsy. Neurosurgery. 2016 Sep; 79(3):345-53.
  20. Muller L, Hamilton LS, Edwards E, Bouchard KE, Chang EF. Spatial resolution dependence on spectral frequency in human speech cortex electrocorticography. J Neural Eng. 2016 Oct; 13(5):056013.

Publications are derived from MEDLINE/PubMed and provided by UCSF Profiles, a service of the Clinical & Translational Science Institute (CTSI) at UCSF. Researchers can make corrections and additions to their publications by logging on to UCSF Profiles.