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Jeffrey Gelfand, M.D.


Dr. Jeffrey Gelfand is a neurologist at the UCSF Multiple Sclerosis Center where he cares for patients with a wide range of inflammatory neurological disorders, including multiple sclerosis (MS), neurosarcoidosis, optic neuritis, transverse myelitis, neuromyelitis optica, encephalitis, chronic meningitis,paraneoplastic syndromes and neurological manifestations of systemic inflammatory disease. He also co-directs the Autoimmune Encephalopathy Clinic, which is part of the UCSF Memory and Aging Center, and directs the Neuroimmunology Clinic at San Francisco General Hospital. Gelfand's research aims to improve diagnosis and treatment for patients with inflammatory diseases of the central nervous system. He is investigating ways of improving care for patients with neurosarcoidosis. He also studies how the visual system can be used to track disease activity in MS.

Gelfand earned a medical degree at Harvard Medical School. He completed an internship in internal medicine, residency in neurology and fellowship in MS and clinical neuroimmunology at UCSF. He is the recipient of a 2011 American Academy of Neurology clinical research training fellowship and is a two-time winner of the San Francisco Neurological Society's Newman Award. Gelfand is a member of the American Academy of Neurology. He is an assistant professor of neurology at UCSF.


Multiple Sclerosis Center
1500 Owens St., Suite 320
San Francisco, CA 94158
Phone: (415) 353-2069
Fax: (415) 353-2633

Hours: Monday to Friday
7:30 a.m. – 6:00 p.m.

More about Jeffrey Gelfand


Harvard School of Medicine 2006


UCSF Medical Center, Neurology 2010


UCSF Medical Center, Multiple Sclerosis and Neuroimmunology 2011

Selected Research and Publications

  1. Gelfand JM. One Brain, Two Specialties, Converging Mechanisms: Neuronal Autoantibodies as a Rare Cause of Postpartum Psychosis. Am J Psychiatry. 2015 Sep 1; 172(9):824-6.
  2. Gelfand JM Stern BJ. Neurosarcoidosis. In: Samuels M, editor. Scientific American Neurology. 2015.
  3. Schlaeger R, Papinutto N, Zhu AH, Lobach IV, Bevan CJ, Bucci M, Castellano A, Gelfand JM, Graves JS, Green AJ, Jordan KM, Keshavan A, Panara V, Stern WA, von Büdingen HC, Waubant E, Goodin DS, Cree BA, Hauser SL, Henry RG. Association Between Thoracic Spinal Cord Gray Matter Atrophy and Disability in Multiple Sclerosis. JAMA Neurol. 2015 Jun 8.
  4. Höftberger R, van Sonderen A, Leypoldt F, Houghton D, Geschwind M, Gelfand J, Paredes M, Sabater L, Saiz A, Titulaer MJ, Graus F, Dalmau J. Encephalitis and AMPA receptor antibodies: Novel findings in a case series of 22 patients. Neurology. 2015 May 15.
  5. Bevan C, Gelfand JM. Therapeutic management of severe relapses in multiple sclerosis. Curr Treat Options Neurol. 2015 Apr; 17(4):345.
  6. Gelfand, JM. Douglas, VC. Harrison's Principles of Internal Medicine. 19th Edition. Edited by Dennis L. Kasper, Anthony S. Fauci, Stephen L. Hauser, Dan L. Longo, J. Larry Jameson, Joseph Loscalzo. Chapter 29: Fatigue. 2015; 151-153.
  7. Gelfand JM, Genrich G, Green AJ, Tihan T, Cree BA. Encephalitis of unclear origin diagnosed by brain biopsy : a diagnostic challenge. JAMA Neurol. 2015 Jan 1; 72(1):66-72.
  8. Gourraud PA, Henry RG, Cree BA, Crane JC, Lizee A, Olson MP, Santaniello AV, Datta E, Zhu AH, Bevan CJ, Gelfand JM, Graves JS, Goodin DS, Green AJ, von Büdingen HC, Waubant E, Zamvil SS, Crabtree-Hartman E, Nelson S, Baranzini SE, Hauser SL. Precision medicine in chronic disease management: The multiple sclerosis BioScreen. Ann Neurol. 2014 Nov; 76(5):633-42.
  9. Gelfand JM, Cotter J, Klingman J, Huang EJ, Cree BA. Massive CNS monocytic infiltration at autopsy in an alemtuzumab-treated patient with NMO. Neurol Neuroimmunol Neuroinflamm. 2014 Oct; 1(3):e34.
  10. Naasan G, Irani SR, Bettcher BM, Geschwind MD, Gelfand JM. Episodic bradycardia as neurocardiac prodrome to voltage-gated potassium channel complex/leucine-rich, glioma inactivated 1 antibody encephalitis. JAMA Neurol. 2014 Oct; 71(10):1300-4.
  11. Ward ME, Taubes A, Chen R, Miller BL, Sephton CF, Gelfand JM, Minami S, Boscardin J, Martens LH, Seeley WW, Yu G, Herz J, Filiano AJ, Arrant AE, Roberson ED, Kraft TW, Farese RV, Green A, Gan L. Early retinal neurodegeneration and impaired Ran-mediated nuclear import of TDP-43 in progranulin-deficient FTLD. J Exp Med. 2014 Sep 22; 211(10):1937-45.
  12. Schlaeger R, Papinutto N, Panara V, Bevan C, Lobach IV, Bucci M, Caverzasi E, Gelfand JM, Green AJ, Jordan KM, Stern WA, von Büdingen HC, Waubant E, Zhu AH, Goodin DS, Cree BA, Hauser SL, Henry RG. Spinal cord gray matter atrophy correlates with multiple sclerosis disability. Ann Neurol. 2014 Oct; 76(4):568-80.
  13. Irani SR, Gelfand JM, Al-Diwani A, Vincent A. Cell-surface central nervous system autoantibodies: clinical relevance and emerging paradigms. Ann Neurol. 2014 Aug; 76(2):168-84.
  14. Irani SR, Gelfand JM, Bettcher BM, Singhal NS, Geschwind MD. Effect of rituximab in patients with leucine-rich, glioma-inactivated 1 antibody-associated encephalopathy. JAMA Neurol. 2014 Jul 1; 71(7):896-900.
  15. Bettcher BM, Gelfand JM, Irani SR, Neuhaus J, Forner S, Hess CP, Geschwind MD. More than memory impairment in voltage-gated potassium channel complex encephalopathy. Eur J Neurol. 2014 Oct; 21(10):1301-10.
  16. Judson MA, Costabel U, Drent M, Wells A, Maier L, Koth L, Shigemitsu H, Culver DA, Gelfand J, Valeyre D, Sweiss N, Crouser E, Morgenthau AS, Lower EE, Azuma A, Ishihara M, Morimoto S, Tetsuo Yamaguchi T, Shijubo N, Grutters JC, Rosenbach M, Li HP, Rottoli P, Inoue Y, Prasse A, Baughman RP, Organ Assessment Instrument Investigators TW. The WASOG Sarcoidosis Organ Assessment Instrument: An update of a previous clinical tool. Sarcoidosis Vasc Diffuse Lung Dis. 2014; 31(1):19-27.
  17. Gelfand JM. Multiple sclerosis: diagnosis, differential diagnosis, and clinical presentation. Handb Clin Neurol. 2014; 122:269-90.
  18. Gelfand JM, Cree BA, Nolan R, Arnow S, Green AJ. Microcystic inner nuclear layer abnormalities and neuromyelitis optica. JAMA Neurol. 2013 May; 70(5):629-33.
  19. Gelfand AA, Gelfand JM, Goadsby PJ. Multiple Sclerosis and Related Disorders. Migraine and multiple sclerosis: Epidemiology and approach to treatment. 2013; 2(2):73-79.
  20. Gelfand AA, Gelfand JM, Goadsby PJ. Migraine and multiple sclerosis: Epidemiology and approach to treatment. Mult Scler Relat Disord. 2013 Apr; 2(2):73-9.

Publications are derived from MEDLINE/PubMed and provided by UCSF Profiles, a service of the Clinical & Translational Science Institute (CTSI) at UCSF. Researchers can make corrections and additions to their publications by logging on to UCSF Profiles.