Factor V assay
The factor V (five) assay is a blood test to measure the activity of factor V. This is one of the proteins in the body that helps the blood clot.
Labile factor; Proaccelerin; Ac-globulin
How the Test is Performed
How to Prepare for the Test
No special preparation is needed.
How the Test will Feel
When the needle is inserted to draw blood, some people feel moderate pain. Others feel only a prick or stinging. Afterward, there may be some throbbing or slight bruising. This soon goes away.
Why the Test is Performed
This test is used to find the cause of too much bleeding (decreased blood clotting). This decreased clotting may be caused by an abnormally low level of factor V.
The value is normally 50% to 200% of the laboratory control or reference value.
Normal value ranges may vary slightly among different laboratories. Some labs use different measurements or may test different samples. Talk to your health care provider about the meaning of your specific test results.
What Abnormal Results Mean
Decreased factor V activity may be related to:
Factor V deficiency(a bleeding disorder that affects the ability of blood to clot)
- Disorder in which the proteins that control blood clotting become over active (
disseminated intravascular coagulation) Liver disease(such as cirrhosis)
- Abnormal breakdown of blood clots (secondary fibrinolysis)
There is little risk involved with having your blood taken. Veins and arteries vary in size from one person to another, and from one side of the body to the other. Obtaining a blood sample from some people may be more difficult than from others.
Other risks associated with having blood drawn are slight but may include:
- Excessive bleeding
- Fainting or feeling lightheaded
- Multiple punctures to locate veins
- Hematoma (blood accumulating under the skin)
- Infection (a slight risk any time the skin is broken)
This test is most often performed on people who have
Chernecky CC, Berger BJ. Factor V (labile factor, proaccelerin, Ac-globulin) - blood. In: Chernecky CC, Berger BJ, eds. Laboratory Tests and Diagnostic Procedures. 6th ed. St Louis, MO: Elsevier Saunders; 2013:502-503.
Pai M. Laboratory evaluation of hemostatic and thrombotic disorders. In: Hoffman R, Benz EJ, Silberstein LE, et al, eds. Hematology: Basic Principles and Practice. 7th ed. Philadelphia, PA: Elsevier; 2018:chap 129.
Review Date: 01/29/2019
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