Robert Edwards, MD


Dr. Robert Edwards is a neurologist and specialist in the treatment of Parkinson's disease who sees patients in the Parkinson's Disease and Movement Disorders Clinic at Parnassus.

In his research, he and his colleagues have identified several proteins implicated in Parkinson's. Edwards earned a medical degree at Johns Hopkins School of Medicine and completed a residency in neurology at UCSF, where he is a professor of neurology and physiology. The recipient of numerous prestigious awards, he earned the Established Investigator Award of the National Alliance for Research on Schizophrenia and Affective Disorders, serves on several editorial boards and the scientific advisory board of the National Parkinson's Foundation.


Parkinson's Disease and Movement Disorders Clinic
400 Parnassus Ave., Eighth Floor
San Francisco, CA 94143
Phone: (415) 353-2273
Fax: (415) 353-2898

Hours: Monday to Friday
8 a.m. – 5 p.m.

Conditions & Treatments

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Johns Hopkins School of Medicine 1980


UCSF, Neurology 1984

Selected Research and Publications

  1. Logan T, Bendor J, Toupin C, Thorn K, Edwards RH. a-Synuclein promotes dilation of the exocytotic fusion pore. Nat Neurosci. 2017 May; 20(5):681-689.
  2. Maas JW, Yang J, Edwards RH. Endogenous Leucine-Rich Repeat Kinase 2 Slows Synaptic Vesicle Recycling in Striatal Neurons. Front Synaptic Neurosci. 2017; 9:5.
  3. Silm K, Edwards RH. One Cycle Fuels Another: The Energetics of Neurotransmitter Release. Neuron. 2017 Feb 08; 93(3):470-472.
  4. Sheng N, Yang J, Silm K, Edwards RH, Nicoll RA. A slow excitatory postsynaptic current mediated by a novel metabotropic glutamate receptor in CA1 pyramidal neurons. Neuropharmacology. 2017 Mar 15; 115:4-9.
  5. Mende M, Fletcher EV, Belluardo JL, Pierce JP, Bommareddy PK, Weinrich JA, Kabir ZD, Schierberl KC, Pagiazitis JG, Mendelsohn AI, Francesconi A, Edwards RH, Milner TA, Rajadhyaksha AM, van Roessel PJ, Mentis GZ, Kaltschmidt JA. Sensory-Derived Glutamate Regulates Presynaptic Inhibitory Terminals in Mouse Spinal Cord. Neuron. 2016 Jun 15; 90(6):1189-202.
  6. Eriksen J, Chang R, McGregor M, Silm K, Suzuki T, Edwards RH. Protons Regulate Vesicular Glutamate Transporters through an Allosteric Mechanism. Neuron. 2016 May 18; 90(4):768-80.
  7. Pathak D, Shields LY, Mendelsohn BA, Haddad D, Lin W, Gerencser AA, Kim H, Brand MD, Edwards RH, Nakamura K. The role of mitochondrially derived ATP in synaptic vesicle recycling. J Biol Chem. 2015 Sep 11; 290(37):22325-36.
  8. Edwards RH. Mobile binding sites regulate glutamate clearance. Nat Neurosci. 2015 Feb; 18(2):166-8.
  9. Berthet A, Margolis EB, Zhang J, Hsieh I, Zhang J, Hnasko TS, Ahmad J, Edwards RH, Sesaki H, Huang EJ, Nakamura K. Loss of mitochondrial fission depletes axonal mitochondria in midbrain dopamine neurons. J Neurosci. 2014 Oct 22; 34(43):14304-17.
  10. Incontro S, Asensio CS, Edwards RH, Nicoll RA. Efficient, complete deletion of synaptic proteins using CRISPR. Neuron. 2014 Sep 03; 83(5):1051-7.
  11. Asensio CS, Sirkis DW, Maas JW, Egami K, To TL, Brodsky FM, Shu X, Cheng Y, Edwards RH. Self-assembly of VPS41 promotes sorting required for biogenesis of the regulated secretory pathway. Dev Cell. 2013 Nov 25; 27(4):425-37.
  12. Sirkis DW, Edwards RH, Asensio CS. Widespread dysregulation of peptide hormone release in mice lacking adaptor protein AP-3. PLoS Genet. 2013; 9(9):e1003812.
  13. Bendor JT, Logan TP, Edwards RH. The function of a-synuclein. Neuron. 2013 Sep 18; 79(6):1044-66.
  14. Foss SM, Li H, Santos MS, Edwards RH, Voglmaier SM. Multiple dileucine-like motifs direct VGLUT1 trafficking. J Neurosci. 2013 Jun 26; 33(26):10647-60.
  15. Hnasko TS, Hjelmstad GO, Fields HL, Edwards RH. Ventral tegmental area glutamate neurons: electrophysiological properties and projections. J Neurosci. 2012 Oct 24; 32(43):15076-85.
  16. Akil O, Seal RP, Burke K, Wang C, Alemi A, During M, Edwards RH, Lustig LR. Restoration of hearing in the VGLUT3 knockout mouse using virally mediated gene therapy. Neuron. 2012 Jul 26; 75(2):283-93.
  17. Cunningham KA, Hua Z, Srinivasan S, Liu J, Lee BH, Edwards RH, Ashrafi K. AMP-activated kinase links serotonergic signaling to glutamate release for regulation of feeding behavior in C. elegans. Cell Metab. 2012 Jul 03; 16(1):113-21.
  18. Wu S, Avila-Sakar A, Kim J, Booth DS, Greenberg CH, Rossi A, Liao M, Li X, Alian A, Griner SL, Juge N, Yu Y, Mergel CM, Chaparro-Riggers J, Strop P, Tampé R, Edwards RH, Stroud RM, Craik CS, Cheng Y. Fabs enable single particle cryoEM studies of small proteins. Structure. 2012 Apr 04; 20(4):582-92.
  19. Blakely RD, Edwards RH. Vesicular and plasma membrane transporters for neurotransmitters. Cold Spring Harb Perspect Biol. 2012 Feb 01; 4(2).
  20. Lee HY, Nakayama J, Xu Y, Fan X, Karouani M, Shen Y, Pothos EN, Hess EJ, Fu YH, Edwards RH, Ptácek LJ. Dopamine dysregulation in a mouse model of paroxysmal nonkinesigenic dyskinesia. J Clin Invest. 2012 Feb; 122(2):507-18.

Publications are derived from MEDLINE/PubMed and provided by UCSF Profiles, a service of the Clinical & Translational Science Institute (CTSI) at UCSF. Researchers can make corrections and additions to their publications by logging on to UCSF Profiles.