Anthony Shum, MD


Dr. Anthony Shum is an associate professor of medicine in the Department of Pulmonary and Critical Care at UCSF. After his clinical fellowship at UCSF, he received research training in immune tolerance as part of the Immunology Program at UCSF. The focus of his lab's research ( is to understand the pathogenesis of autoimmune lung diseases by intensively studying patients with these disorders and modeling their disease in mice. Through Shum's work he identified a novel lung-specific antigen named BPIFB1 that is targeted in patients with autoimmune lung disease and demonstrated that autoantibodies to BPIFB1 could be used as a biomarker to detect patients with lung autoimmunity. His lab also recently helped discover the genetic basis of a novel Mendelian syndrome of autoimmunity manifested by lung and joint disease that is coined the COPA syndrome, based on the gene that is mutated in this disorder. Through his research Shum hopes to discover diagnostic and interventional targets that will ultimately lead to biomarkers and therapies that will directly impact patient care.


ILD Program
400 Parnassus Ave., Fifth Floor
San Francisco, CA 94143
Phone: (415) 353-2577
Fax: (415) 353-8944

Conditions & Treatments

  • COPA Syndrome

Academic Title

Associate Professor

More about Anthony Shum


University of Chicago Pritzker School of Medicine 2000


Boston University Medical Center, Internal Medicine 2003


UCSF Medical Center, Pulmonary 2009

Selected Research and Publications

  1. Volpi S, Tsui J, Mariani M, Pastorino C, Caorsi R, Sacco O, Ravelli A, Shum AK, Gattorno M, Picco P. Type I interferon pathway activation in COPA syndrome. Clin Immunol. 2018 Feb; 187:33-36.
  2. Chung SA, Shum AK. Rare variants, autoimmune disease, and arthritis. Curr Opin Rheumatol. 2016 Jul; 28(4):346-51.
  3. Shum AK. T cell types that take your breath away. Sci Transl Med. 2015 Aug 19; 7(301):301fs33.

Publications are derived from MEDLINE/PubMed and provided by UCSF Profiles, a service of the Clinical & Translational Science Institute (CTSI) at UCSF. Researchers can make corrections and additions to their publications by logging on to UCSF Profiles.