Leber Congenital Amaurosis (LCA)
Signs and Symptoms
Babies born with LCA have very reduced vision that can often be detected by parents in the first few months of life. They may not respond to visual cues and have roving eye movements, called nystagmus. Many children with LCA habitually press on their eyes with their fists or fingers, which causes eyes to look sunken or deep set.
Less common symptoms include cataracts, corneal abnormality (keratoconus), aversion to light (photophobia), hearing impairment and developmental delays, epilepsy and motor skill impairment. Over time, the retina deteriorates; retinal blood vessels can become thin and narrow and undergo pigmentary changes.
UCSF Health medical specialists have reviewed this information. It is for educational purposes only and is not intended to replace the advice of your doctor or other health care provider. We encourage you to discuss any questions or concerns you may have with your provider.