Melissa Zimel, MD

Orthopedic surgeon

Dr. Melissa Zimel is an orthopedic surgeon who specializes in diagnosing and treating children and adults with bone or soft tissue tumors, or with conditions caused by tumors. As an orthopedic oncologist, she evaluates and treats benign and malignant tumors of the extremities, pelvis and trunk. For patients who need a cancerous bone tumor removed, she performs limb salvage surgery, which can involve joint reconstruction with custom implants. She also treats patients with metastatic bone cancer.

Zimel's research focuses on optimizing outcomes for patients with musculoskeletal tumors who have had limbs amputated, or preserved and reconstructed using implants. Her studies include patients who have had one or multiple surgeries.

After earning her medical degree at Northwestern University Feinberg School of Medicine, Zimel completed a residency in orthopedic surgery at William Beaumont Hospital. She then completed a fellowship in orthopedic oncology at Memorial Sloan Kettering Cancer Center.

Zimel is an assistant professor of clinical orthopedic surgery at UCSF. She belongs to the following organizations: Musculoskeletal Tumor Society, American Academy of Orthopaedic Surgeons, Orthopaedic Research Society, Ruth Jackson Orthopaedic Society, J. Robert Gladden Orthopaedic Society and American Medical Association.


Orthopedic Surgical Oncology
1825 Fourth St., Fourth Floor
San Francisco, CA 94158
Phone: (415) 885-3800
Fax: (415) 514-5661

Hours: Monday to Friday
8 a.m. – 5 p.m.

Academic Title

Assistant Professor

More about Melissa Zimel


Northwestern University Feinberg School of Medicine 2008


William Beaumont Hospital, Orthopedic Surgery 2013


Memorial Sloan Kettering Cancer Center, Orthopedic Oncology 2015

Selected Research and Publications

  1. Weiss KR, Zimel MN. Considerations for the Long Term Treatment of Pediatric Sarcoma Survivors. Indian J Orthop. 2018 Jan-Feb; 52(1):77-80.
  2. Zimel MN, Horowitz CB, Rajasekhar VK, Christ AB, Wei X, Wu J, Wojnarowicz PM, Wang D, Goldring SR, Purdue PE, Healey JH. HPMA-Copolymer Nanocarrier Targets Tumor-Associated Macrophages in Primary and Metastatic Breast Cancer. Mol Cancer Ther. 2017 Dec; 16(12):2701-2710.
  3. Nakajima K, Kho DH, Yanagawa T, Zimel M, Heath E, Hogan V, Raz A. Galectin-3 in bone tumor microenvironment: a beacon for individual skeletal metastasis management. Cancer Metastasis Rev. 2016 Jun; 35(2):333-46.

Publications are derived from MEDLINE/PubMed and provided by UCSF Profiles, a service of the Clinical & Translational Science Institute (CTSI) at UCSF. Researchers can make corrections and additions to their publications by logging on to UCSF Profiles.