Skip to Main Content

Andrew D. Krystal



Dr. Andrew Krystal is a psychiatrist who cares for adults with all types of sleep disorders, with particular expertise in insomnia. He also treats patients who have mood and anxiety spectrum disorders in addition to sleep disorders. An internationally renowned expert on sleep and mood disorders, he has more than 25 years of experience in patient care and research.

Krystal's research focuses on understanding insomnia's causes and how insomnia may be related to psychiatric or other medical conditions. He also studies new treatments for insomnia and other sleep disorders, as well as how sleep maintains and restores normal human functions.

After completing a master's degree in biomedical engineering at the Massachusetts Institute of Technology, Krystal earned his medical degree at Duke University School of Medicine. He then completed a residency in psychiatry at Duke, followed by fellowships in sleep medicine and clinical neurophysiology (studying the nervous system through recording the body's electrical activity). In addition to holding various leadership positions, he served as a faculty member and physician at Duke Health for more than two decades before joining UCSF in 2016.

Krystal is president of the Sleep Research Society and a member of the American Academy of Sleep Medicine, American Psychiatric Association and American College of Neuropsychopharmacology. He serves on the examination committee of the American Board of Sleep Medicine, which allows medical professionals to pursue certification in sleep medicine.

  • Education

    Duke University School of Medicine, 1987

    MIT, MS, Biomedical Engineering, 1983

  • Residencies

    Duke University, Psychiatry, 1991

  • Fellowships

    Duke University, Sleep Medicine and Clinical Neurophysiology, 1993

  • Board Certifications

    Psychiatry, American Board of Psychiatry and Neurology.

  • Academic Title


Where I see patients (1)

    Decorative Caduceus

    Closed-Loop Deep Brain Stimulation for Major Depression

    Effect size of active compared to sham stimulation (mean difference in Montgomery Asberg Depression Rating Scale (MADRS) score before and after the sham and treatment periods). Higher MADRS score indicates more severe depression; ...


    Decorative Caduceus

    Personalized DBS for OCD Guided by Stereoencephalography Mapping

    Percentage of patients in which the investigators can identify a stimulation target that acutely improves OCD symptoms during the SEEG Stage 1


    Decorative Caduceus

    Diet and Depression

    Percent of enrolled of participants who have reduced their ultra-processed food intake


    Decorative Caduceus

    Biomarkers of Depression and Treatment Response

    Effect size of active stimulation (mean difference in Montgomery Asberg Depression Rating Scale (MADRS) score) before and after morning and afternoon treatment course. Higher MADRS score indicates more severe depression; the overa...


    Decorative Caduceus

    Tissue-specific Insulin Resistance in Obstructive Sleep Apnea: Role of Hypoxia

    The percent of newly synthesized fatty acids (DNL, %) will be measured using a stable isotope (deuterated water) and mass spectrometry.