Zhonghui Guan, MD

Pain management physician

Dr. Zhonghui Guan is an anesthesiologist and pain management specialist at the Pain Management Center at UCSF Medical Center. He specializes in treating chronic pain, including low back pain and neck pain, neuropathic pain, complex regional pain syndrome, failed back surgery syndrome and cancer pain.

In his research, he focuses on better understanding gene expression regulation in chronic pain. He earned a medical degree at Peking Union Medical School in Beijing, China, and completed an anesthesia residency at Massachusetts General Hospital in Boston, followed by a pain management fellowship at UCSF. He is a member of numerous professional organizations, including the American Society of Anesthesiologists, California Society of Anesthesiologists and Society for Neuroscience. He is an associate professor at UCSF.


Pain Management Center
2255 Post St.
San Francisco, CA 94143-1654
Phone: (415) 885-PAIN (7246)
New Patients: (415) 885-3552
Fax: (415) 885-3883

Hours: Monday to Friday
8 a.m. – 5 p.m.

Conditions & Treatments

Board Certification

Pain Medicine

More about Zhonghui Guan

Additional Languages



Peking Union School of Medicine 1994


Massachusetts General Hospital, Anesthesia 2006


UCSF Medical Center, Pain Management 2009

Selected Research and Publications

  1. Guan Z, Hellman J, Schumacher M. Contemporary views on inflammatory pain mechanisms: TRPing over innate and microglial pathways. F1000Res. 2016; 5.
  2. Guan Z, Kuhn JA, Wang X, Colquitt B, Solorzano C, Vaman S, Guan AK, Evans-Reinsch Z, Braz J, Devor M, Abboud-Werner SL, Lanier LL, Lomvardas S, Basbaum AI. Injured sensory neuron-derived CSF1 induces microglial proliferation and DAP12-dependent pain. Nat Neurosci. 2016 Jan; 19(1):94-101.
  3. Bráz JM, Wang X, Guan Z, Rubenstein JL, Basbaum AI. Transplant-mediated enhancement of spinal cord GABAergic inhibition reverses paclitaxel-induced mechanical and heat hypersensitivity. Pain. 2015 Jun; 156(6):1084-91.
  4. Solorzano C, Villafuerte D, Meda K, Cevikbas F, Bráz J, Sharif-Naeini R, Juarez-Salinas D, Llewellyn-Smith IJ, Guan Z, Basbaum AI. Primary afferent and spinal cord expression of gastrin-releasing peptide: message, protein, and antibody concerns. J Neurosci. 2015 Jan 14; 35(2):648-57.
  5. Guan Z, Baker K, Sandberg WS. Misalignment of disposable pulse oximeter probes results in false saturation readings that influence anesthetic management. Anesth Analg. 2009 Nov; 109(5):1530-3.
  6. Yu JX, Guan Z, Nash HA. The mushroom body defect gene product is an essential component of the meiosis II spindle apparatus in Drosophila oocytes. Genetics. 2006 May; 173(1):243-53.
  7. Levine AA, Guan Z, Barco A, Xu S, Kandel ER, Schwartz JH. CREB-binding protein controls response to cocaine by acetylating histones at the fosB promoter in the mouse striatum. Proc Natl Acad Sci U S A. 2005 Dec 27; 102(52):19186-91.
  8. Guan Z, Kim JH, Lomvardas S, Holick K, Xu S, Kandel ER, Schwartz JH. p38 MAP kinase mediates both short-term and long-term synaptic depression in aplysia. J Neurosci. 2003 Aug 13; 23(19):7317-25.
  9. Guan Z, Giustetto M, Lomvardas S, Kim JH, Miniaci MC, Schwartz JH, Thanos D, Kandel ER. Integration of long-term-memory-related synaptic plasticity involves bidirectional regulation of gene expression and chromatin structure. Cell. 2002 Nov 15; 111(4):483-93.
  10. Guan Z, Prado A, Melzig J, Heisenberg M, Nash HA, Raabe T. Mushroom body defect, a gene involved in the control of neuroblast proliferation in Drosophila, encodes a coiled-coil protein. Proc Natl Acad Sci U S A. 2000 Jul 05; 97(14):8122-7.
  11. Guan Z, Scott RL, Nash HA. A new assay for the genetic study of general anesthesia in Drosophila melanogaster: use in analysis of mutations in the X-chromosomal 12E region. J Neurogenet. 2000 Apr; 14(1):25-42.

Publications are derived from MEDLINE/PubMed and provided by UCSF Profiles, a service of the Clinical & Translational Science Institute (CTSI) at UCSF. Researchers can make corrections and additions to their publications by logging on to UCSF Profiles.