Carolyn S. Calfee, MD

Pulmonologist

Dr. Carolyn Calfee cares for patients in the intensive care units at UCSF Medical Center. She is also a member of UCSF's Center for Tobacco Control Research and Education and an associate member of the UCSF Cancer Center.

Calfee's primary research focus is the prevention, diagnosis, prognosis and treatment of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). Her current research projects include the role of biomarkers in investigating ALI/ARDS pathogenesis, early diagnosis, treatment and prognosis; the role of cigarette smoke exposure in susceptibility to lung injury; and novel treatments for acute lung injury.

Calfee received her undergraduate degree from Yale University and her medical degree from the University of Pennsylvannia School of Medicine. She came to UCSF for residency in internal medicine, and stayed to complete her chief residency and pulmonary/critical care medicine fellowship. She also completed a master's degree in clinical research at UCSF in 2009. After research training with Dr Michael Matthay and Dr. Mark Eisnere, she joined the UCSF faculty in 2007. She is an associate professor in residence of medicine and anesthesia.

Academic Title

Associate Professor

More about Carolyn S. Calfee

Additional Languages

French

Education

University of Pensylvannia School of Medicine 1999

Residencies

UCSF Medical Center, Internal Medicine 2002

Fellowships

UCSF Medical Center, Pulmonary Medicine 2007

Selected Research and Publications

  1. Robles AJ, Kornblith LZ, Hendrickson CM, Howard BM, Conroy AS, Moazed F, Calfee CS, Cohen MJ, Callcut RA. Health Care Utilization and the Cost of Post-Traumatic ARDS Care. J Trauma Acute Care Surg. 2018 Apr 02.
  2. Gotts JE, Chun LF, Abbott J, Fang X, Takasaki N, Nishimura SL, Springer ML, Schick SF, Calfee CS, Matthay MA. Cigarette smoke exposure worsens acute lung injury in antibiotic-treated bacterial pneumonia in mice. Am J Physiol Lung Cell Mol Physiol. 2018 Mar 15.
  3. Panzer AR, Lynch SV, Langelier C, Christie JD, McCauley K, Nelson M, Cheung CK, Benowitz NL, Cohen MJ, Calfee CS. Lung Microbiota Is Related to Smoking Status and to Development of Acute Respiratory Distress Syndrome in Critically Ill Trauma Patients. Am J Respir Crit Care Med. 2018 Mar 01; 197(5):621-631.
  4. Delucchi K, Famous KR, Ware LB, Parsons PE, Thompson BT, Calfee CS. Stability of ARDS subphenotypes over time in two randomised controlled trials. Thorax. 2018 Feb 24.
  5. Lefranšais E, Mallavia B, Zhuo H, Calfee CS, Looney MR. Maladaptive role of neutrophil extracellular traps in pathogen-induced lung injury. JCI Insight. 2018 Feb 08; 3(3).
  6. Moazed F, Hendrickson C, Nelson M, Conroy A, Cohen MJ, Calfee CS. Platelet aggregation after blunt trauma is associated with the acute respiratory distress syndrome and altered by cigarette smoke exposure. J Trauma Acute Care Surg. 2018 Feb; 84(2):365-371.
  7. Howard BM, Kornblith LZ, Redick BJ, Conroy AS, Nelson MF, Calfee CS, Callcut RA, Cohen MJ. Exposing the bidirectional effects of alcohol on coagulation in trauma: Impaired clot formation and decreased fibrinolysis in rotational thromboelastometry. J Trauma Acute Care Surg. 2018 Jan; 84(1):97-103.
  8. Chun LF, Moazed F, Calfee CS, Matthay MA, Gotts JE. Reply to "Letter to the Editor: Pulmonary toxicity of electronic cigarettes: more doubts than certainties". Am J Physiol Lung Cell Mol Physiol. 2017 Nov 01; 313(5):L966-L967.
  9. Calfee CS, Delucchi K, Famous KR. Reply: Next Step to Understanding Subphenotypes of Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med. 2017 09 15; 196(6):796.
  10. Gotts JE, Abbott J, Fang X, Yanagisawa H, Takasaka N, Nishimura SL, Calfee CS, Matthay MA. Cigarette Smoke Exposure Worsens Endotoxin-Induced Lung Injury and Pulmonary Edema in Mice. Nicotine Tob Res. 2017 Sep 01; 19(9):1033-1039.
  11. Mehta S, Burns KEA, Machado FR, Fox-Robichaud AE, Cook DJ, Calfee CS, Ware LB, Burnham EL, Kissoon N, Marshall JC, Mancebo J, Finfer S, Hartog C, Reinhart K, Maitland K, Stapleton RD, Kwizera A, Amin P, Abroug F, Smith O, Laake JH, Shrestha GS, Herridge MS. Gender Parity in Critical Care Medicine. Am J Respir Crit Care Med. 2017 Aug 15; 196(4):425-429.
  12. Zhao Z, Wickersham N, Kangelaris KN, May AK, Bernard GR, Matthay MA, Calfee CS, Koyama T, Ware LB. External validation of a biomarker and clinical prediction model for hospital mortality in acute respiratory distress syndrome. Intensive Care Med. 2017 Aug; 43(8):1123-1131.
  13. Meyer NJ, Calfee CS. Novel translational approaches to the search for precision therapies for acute respiratory distress syndrome. Lancet Respir Med. 2017 Jun; 5(6):512-523.
  14. Chun LF, Moazed F, Calfee CS, Matthay MA, Gotts JE. Pulmonary toxicity of e-cigarettes. Am J Physiol Lung Cell Mol Physiol. 2017 Aug 01; 313(2):L193-L206.
  15. Zinter MS, Orwoll BE, Spicer AC, Alkhouli MF, Calfee CS, Matthay MA, Sapru A. Incorporating Inflammation into Mortality Risk in Pediatric Acute Respiratory Distress Syndrome. Crit Care Med. 2017 May; 45(5):858-866.
  16. Bos LD, Schouten LR, van Vught LA, Wiewel MA, Ong DSY, Cremer O, Artigas A, Martin-Loeches I, Hoogendijk AJ, van der Poll T, Horn J, Juffermans N, Calfee CS, Schultz MJ. Identification and validation of distinct biological phenotypes in patients with acute respiratory distress syndrome by cluster analysis. Thorax. 2017 10; 72(10):876-883.
  17. Moazed F, Calfee CS. The Canary in the Coal Mine Is Coughing: Electronic Cigarettes and Respiratory Symptoms in Adolescents. Am J Respir Crit Care Med. 2017 04 15; 195(8):974-976.
  18. Hendrickson CM, Abbott J, Zhuo H, Liu KD, Calfee CS, Matthay MA. Higher mini-BAL total protein concentration in early ARDS predicts faster resolution of lung injury measured by more ventilator-free days. Am J Physiol Lung Cell Mol Physiol. 2017 May 01; 312(5):L579-L585.
  19. Famous KR, Delucchi K, Ware LB, Kangelaris KN, Liu KD, Thompson BT, Calfee CS. Acute Respiratory Distress Syndrome Subphenotypes Respond Differently to Randomized Fluid Management Strategy. Am J Respir Crit Care Med. 2017 Feb 01; 195(3):331-338.
  20. Bhatraju PK, Mukherjee P, Robinson-Cohen C, O'Keefe GE, Frank AJ, Christie JD, Meyer NJ, Liu KD, Matthay MA, Calfee CS, Christiani DC, Himmelfarb J, Wurfel MM. Acute kidney injury subphenotypes based on creatinine trajectory identifies patients at increased risk of death. Crit Care. 2016 11 17; 20(1):372.

Publications are derived from MEDLINE/PubMed and provided by UCSF Profiles, a service of the Clinical & Translational Science Institute (CTSI) at UCSF. Researchers can make corrections and additions to their publications by logging on to UCSF Profiles.