Asthma Clinic

PrecISE (Precision Interventions for Severe and/or Exacerbation-Prone Asthma) Network Study

The primary objective of this study is to evaluate several interventions given to participants with severe asthma. Interventions are administered in a crossover manner with 16-week treatment periods followed by 8 to ...

Recruiting

The Effect of NAC on Lung Function and CT Mucus Score

This study evaluates 20% n-acetylcysteine (NAC) in the treatment of moderate-to-severe asthma that is complicated by mucus in the airway, as determined by CT imaging. The study is a crossover design, which means that...

Recruiting

Mechanisms of Exacerbation of Asthma

The purpose of this study is to identify the causes of asthma that were not previously suspected, to better understand the effects of inhaled steroids on asthma and to identify new way to treat asthma.

Recruiting

RETHINC: REdefining THerapy In Early COPD for the Pulmonary Trials Cooperative

The study hypothesis is that symptomatic current and former smokers with spirometric values within the normal range (post-bronchodilator FEV1/FVC≥0.70 and post-BD FVC ≥ 70% predicted will still derive symptomatic ben...

Recruiting

CF And Effects of Drugs Mixed Ex Vivo With Sputum for Mucolytic Treatment

The investigators will collect samples of sputum from healthy volunteers and patients with cystic fibrosis for the purpose of: a) purifying airway mucins for plate-based binding studies and; b) assessment of the effe...

Recruiting

Characterization of Adult Subjects for Asthmatic Research Studies

This study is designed to characterize subjects in terms of the nature and severity of their asthma and in terms of conditions that may alter the clinical expression of asthma. Some features will be obtained in all s...

Recruiting

Study of the Inflammation and Airway Changes That Occur After Exposure to Allergen in Asthmatic...

This protocol describes a single site mechanistic study to investigate microRNAs (miRNAs) that are differentially expressed in the airway epithelium of patients with asthma at baseline and in response to allergen cha...

Recruiting

Characterizing Asthma Sputum Elasticity in the UCSF Severe Asthma Research Program

This study is designed to characterize subjects in terms of their sputum phenotype. The purpose of this study is to learn more about the impact of having abnormally elastic sputum on asthma severity by comparing subj...

Recruiting