Asthma Clinic

Impact of Metabolic Dysfunction and Mucus Plugging on Asthma Physiology

We will compare change in EELV during the CPET (Cardiopulmonary Exercise Test) between the obese asthma patients with MD or without MD and between the patients with severe asthma with mucus plugs or without mucus plugs.

Recruiting

SPIROMICS Study of Early COPD Progression (SOURCE)

Parametric Response Mapping captures the change in lung density between matched inspiratory and expiratory images thereby enabling the distinction between normal lung parenchyma (PRMNORM), emphysema (PRMEMPH), and non-emphysematou...

Recruiting

Tissue Immune Interaction in Nasal Polyposis

This study enrolls chronic rhinosinusitis patients with and without nasal polyps. Investigators aim to compare the percentage of ILC2 and tuft cells present in nasal tissue and secretions between those who present with nasal polyp...

Recruiting

Lung Function Outcomes Following Removal of Airway Mucus Plugs in Patients With Asthma (FOCUS)

We will assess change from baseline FEV1 one week after and six months after removal of mucus plugs by bronchoscopy.

Recruiting

PrecISE (Precision Interventions for Severe and/or Exacerbation-Prone Asthma) Network Study

Assessed prior to bronchodilator administration. Efficacy analyses will compare the end-of-period outcome values between test treatment and placebo.

Recruiting

Blood Lymphocytes in Asthmatics Treated With Therapeutic Proteins

The investigators will compare lymphocyte counts in healthy controls to asthmatics on and off therapeutic proteins.

Recruiting

CF And Effects of Drugs Mixed Ex Vivo With Sputum for Mucolytic Treatment

Recruiting

The Effect of NAC on Lung Function and CT Mucus Score

The primary outcome is the % change in FEV1 from the start to the end of each two-week treatment period (either placebo or 20% NAC).

Recruiting