Skip to Main Content

Peyronie's Disease


Peyronie's disease is a disorder affecting about three percent of men middle-age and older. The condition is caused by the formation of dense, fibrous scar tissue, or plaque, in the penis' tunica albuginea, the sheath that surrounds the erectile tissue.

The cause of Peyronie's disease is not completely known. However, factors such as genetics and trauma to the penis, which can occur due to injury or invasive penile procedures, may contribute to the disease.

Our approach to Peyronie's disease

UCSF is a national leader in treating urological disorders, including Peyronie's disease, male sexual dysfunction, urinary incontinence, pelvic pain, urinary stone disease, male infertility and prostate disease. We offer the latest treatment techniques, and our team is committed to providing innovative, highly skilled care with compassion.

In a small percentage of cases, Peyronie's disease resolves on its own. When treatment is required, our goals are to relieve symptoms and preserve erectile function. We may use oral medications, injections or – in persistent cases – surgery.

Awards & recognition

  • usnews-neurology

    Among the top hospitals in the nation

  • usnews-urology

    Best in Northern California for urology

  • n1-2x

    in NIH funding for urology research

Signs & symptoms

Due to the formation of scar tissue in the penis, patients with Peyronie's disease may experience pain and a curvature or distortion, such as a shortening or narrowing of the penis, during an erection. In severe cases, these symptoms may lead to erectile dysfunction.


A diagnosis of Peyronie's disease usually can be made by taking a detailed medical history and conducting a thorough physical examination. Your doctor will check for and discuss any symptoms that are related to the disease. In some instances, an ultrasound scan may be used to identify the hardened plaque in the penis.

We recommend that patients bring photographs from a digital or polaroid camera of the erect penis taken from above and both sides, if possible. These can be very helpful in making a diagnosis.

In rare cases where a diagnosis of Peyronie's disease cannot be made through physical examination, a biopsy may be recommended. During a biopsy, a small amount of plaque cells are removed from the penis and then examined under a microscope to help diagnose the condition and rule out other diseases, such as cancer.


In about 15 percent of cases, Peyronie's disease spontaneously resolves itself without treatment. However, more than 40 percent of cases may worsen. If treatment is necessary, oral medications, injections and surgery may be used. Therapy for the condition aims to relieve symptoms and preserve erectile function.


  • Oral medications. Taking a drug known as para-aminobenzoate or vitamin E tablets may be recommended for several months. Unfortunately, in most cases, these medications have limited success. At UCSF Medical Center, our experts pioneered new treatments, such as colchicine and pentoxifylline, that have better success.
  • Injections. The injection of verapamil into the plaque in the penis may be recommended. This treatment typically requires about six to 12 injections over six months duration.
  • Iontophoresis. This is a technique in which a painless current of electricity is used to deliver verapamil or some other agent under the skin into the plaque.


Surgery has been shown to be the most effective treatment for Peyronie's disease to correct the curvature of the penis. However, it is usually only recommended in severe cases for patients who fail to respond to non-surgical therapy and have curvature for longer than 12 months.

The two most common surgical methods are the cutting of the plaque followed by placement of a patch of vein or artificial material, or stitching of tissue from the side of the penis opposite the plaque, which corrects the penile curvature.

Some men choose to receive an implanted device, or penile prosthesis, that increases the rigidity of the penis. In some cases, a penile implant alone will adequately straighten the penis.

For more detailed information on the three surgical procedures offered at UCSF Medical Center, please see Surgical Treatment for Peyronie's Disease.

UCSF Health medical specialists have reviewed this information. It is for educational purposes only and is not intended to replace the advice of your doctor or other health care provider. We encourage you to discuss any questions or concerns you may have with your provider.

Recommended reading

Penile Injections: A Patient Guide

Although you probably find the idea of injecting something into your penis unappealing, many men are highly satisfied with this therapy. Learn why here.

Surgical Treatment for Peyronie's Disease

Surgery has been shown to be the most effective treatment for Peyronie's disease in correcting the curvature of the penis. Learn more here.

Where to get care (1)

    Support services

    Patient Resource

    Case Management & Social Work

    Connect with a team that can help you find resources, solve problems and advocate for you during treatment at UCSF.


    Mindfulness-Based Stress Reduction Class

    This eight-week class teaches mindfulness practices that can reduce stress and improve your overall health, such as meditation and body awareness.

    Patient Resource

    Patient Relations

    We welcome feedback about your experience at UCSF Health. Find out how to contact us with comments, questions or concerns.

    Patient Resource

    Spiritual Care Services

    Chaplains representing many faiths are available around the clock to provide support, comfort and counsel to patients, families and caregivers.