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Transposition of the Great Arteries


Transposition of the great arteries is when the two major arteries leaving the heart are connected to the wrong ventricles, the lower pumping chambers of the heart. The result is that blood containing oxygen from the lungs is pumped back into the lungs. Blood that lacks oxygen, which is necessary to nourish the body, is pumped throughout the body.

The heart consists of four chambers. There are two upper chambers, called atria, where blood enters the heart; and the two lower chambers, called ventricles, where blood is pumped out of the heart. The flow between the chambers and between the arteries is controlled by a set of valves that act as one-way doors. The heart also can be viewed as two side-by-side pumps with one side — an atrium and a ventricle with valves connecting them to blood vessels — pumping blood into the lungs and the other side pumping blood from the lungs back to the body.

Blood is pumped from the right side of the heart up through the pulmonary valve and the pulmonary artery to the lungs. In the lungs, blood is filled with oxygen. From the lungs, the blood travels back down to the heart's left atrium and left ventricle. Then, it's pumped through a big blood vessel called the aorta to the rest of the body.

Our Approach to Transposition of the Great Arteries

UCSF provides comprehensive, highly specialized care for adults living with heart defects such as transposition of the great arteries. Our dedicated team of experts offers a wide array of services, including thorough medical evaluations, advanced treatments, long-term monitoring, and personalized recommendations on diet, exercise, psychosocial support and family planning.

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  • Among the top hospitals in the nation

  • One of the nation's best for heart & vascular surgery

Signs & symptoms

A baby with transposed arteries is blue, or cyanotic, shortly after birth. The blueness doesn't go away even if the baby is given extra oxygen. For a baby with transposed arteries to survive, blood flow between the right and left sides of the heart must be increased. These infants rarely survive without surgical intervention so it is extremely rare for a person to grow to adulthood without treatment.


A complete transposition usually is diagnosed shortly after birth due to the baby's increasing blue coloration or cyanosis. There may or may not be a heart murmur or extra sound in the heartbeat.

Tests may include:

  • Oxygen saturation test to check the level of oxygen in the blood Electrocardiogram (EKG or ECG), which records the heart's electrical activity
  • Chest X-ray to see the heart's size
  • Echocardiogram, which is an ultrasound examination of the heart

In addition, a cardiac catheterization procedure may be used to inject a dye into the heart and to see on a moving picture X-ray how the heart is functioning.


Currently, permanent treatment requires a surgical procedure to switch the arteries to their proper places. This operation, called an arterial switch operation, is done within the first few weeks of life. It is an open-heart procedure that requires a temporary stopping of the baby's heart while a heart-lung machine handles respiration and blood circulation. Any abnormal holes between the ventricles or atria also are closed. As part of the procedure the coronary arteries — the arteries that supply blood to the heart — have to be taken off their normal position on the aorta and transplanted into the new "aorta" that now carries oxygenated blood from the left ventricle around the body. Rarely, this may be lead to problems that require further procedures.

Most adults with transposition of the great arteries have been treated with a different operation that created an atrial switch and corrected the path of blood flow. These operations carry the names of the surgeons who first described them, the Senning or the Mustard procedure. The most common complications to arise from these types of operations include heart failure, abnormal heart rhythms and leaks in the "baffle" that diverts the blood flow along the right path. Nevertheless, many adults lead relatively normal lives and women have had successful pregnancies.

Patients who have this condition need follow-up care by a cardiologist who specializes in congenital heart disease for the rest of their lives to monitor any subsequent complications. A woman who has had surgery for transposition of the great arteries should have a thorough evaluation before contemplating pregnancy. All patients with transposition of the great vessels should be prescribed antibiotics before surgery or dental procedures to protect against endocarditis.

UCSF Health medical specialists have reviewed this information. It is for educational purposes only and is not intended to replace the advice of your doctor or other health care provider. We encourage you to discuss any questions or concerns you may have with your provider.

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