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Marc Simon


Director, Pulmonary Vascular Disease and Pulmonary Hypertension Clinic

Dr. Marc Simon is a cardiologist who specializes in pulmonary hypertension (a type of high blood pressure affecting the right side of the heart), advanced heart failure and heart transplantation. Among the patients he cares for are those with right-sided heart failure, which can result from pulmonary hypertension. He has experience with all methods of diagnosis, including right heart catheterization (in which a small tube called a catheter is threaded through a blood vessel to reach the heart), performing the test with patients at rest as well as during exercise. He directs UCSF's programs in pulmonary vascular disease and pulmonary hypertension.

Simon's research focuses primarily on developing new therapies for pulmonary hypertension as well as a better understanding of right-sided heart failure in patients with that condition.

He also has applied his background in bioengineering to heart biomechanics, studying how the heart can fail in cases of pulmonary hypertension. He has helped design several clinical trials (studies using human volunteers to evaluate promising new treatments) and directs ongoing trials of new medications and devices for pulmonary hypertension and heart failure.

Simon earned his medical degree from the University of Maryland School of Medicine. He completed a residency in cardiology at the University of Colorado School of Medicine. He completed a fellowship in cardiology and heart failure and a fellowship in cardiac transplantation at the University of Pittsburgh.

  • Education

    University of Maryland School of Medicine, MD, 1998

  • Residencies

    University of Colorado School of Medicine, Cardiology, 2001

  • Fellowships

    University of Pittsburgh, Cardiology and Heart Failure, 2004

    University of Pittsburgh, Cardiac Transplantation, 2005

  • Academic Title


Where I see patients (3)

    My reviews


    Overall Experience
    82 Ratings
    About our process
    Nov 15, 2023
    Perfect everything thank you very much
    Sep 18, 2023
    Zero complaints - All Good!!
    Sep 08, 2023
    Learning more about my condition
    Sep 06, 2023
    Very much impressed with how everyone took care of me
    Sep 05, 2023
    I just love it when a doctor says things like let's look at the overall picture let's put all we know together with the data. I can't remember if this is exactly what he said but you get the point. It is very reassuring to think that someone is doing this for me. He wasn't just checking his box. He Is amazing keep him happy and give him a raise.
    Jul 06, 2023
    Dr. Simon made me feel that I was his only patient/concern at that moment which a good!!
    Jun 22, 2023
    Dr Marc Simon was outstanding with how he spent time with me he was present during the echocardiogram and the consultation after was extremely thorough! My husband and I appreciate the time he spent with explanations and details.
    Jun 22, 2023
    The best team of doctors I had in a long time.
    May 14, 2023
    I am grateful for DR Simon and his team
    Mar 23, 2023
    Dr marc simon is an excellent and an extremely attentive physician. He explained my medical situation thoroughly and explained what options I was faced with. He took his time and his knowledge was impeccable.
    Mar 13, 2023
    Jan 20, 2023
    I am very pleased with the quality of service and attention I received from my providers
    Dec 03, 2022
    Both my husband and I were extremely impressed with Dr Simon. He's extremely knowledgeable l kind and caring and I appreciate very much that he is willing to assist me
    Nov 12, 2022
    Outstanding experience! Dr Simon couldn't have been better. Explanations and compassion combined with a very kind way of being really helped me.
    Nov 10, 2022
    The Dr. Was very nice. Explained everything I needed to know.
    Sep 16, 2022
    The doctor we had was phenomenal. He was extremely thorough and explained everything and answered all of our questions and concerns.
    Aug 23, 2022
    I very much appreciated Dr Simon's bedside manner. I felt comfortable and am very thankful to have him on my team.
    Apr 08, 2022
    Best experience ever
    Feb 10, 2022
    Positive experience
    Decorative Caduceus

    Reducing Right Ventricular Failure in Pulmonary Arterial Hypertension (RELIEVE-PAH)

    Percentage of Treatment group patients experiencing any device-related Major Adverse Cardiovascular or Neurological Events (MACNE) during the first 90-days after implantation


    Decorative Caduceus

    Metformin for Pulmonary Hypertension HFpEF


    Decorative Caduceus

    A Study of a Mean Pulmonary Artery Pressure-Targeted Approach With Early and Rapid Treprostinil...