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Simon Little


Hiking and seawater lover

Dr. Simon Little is a neurologist who specializes in caring for patients with movement disorders, including Parkinson's disease, tremor and dystonia (involuntary muscle contractions that can cause repetitive movements and abnormal posture). He has a particular interest in using deep brain stimulation (surgically implanted electrodes to regulate areas of the brain that trigger abnormal activity) to treat symptoms such as muscle stiffness, slowness and tremors when they haven't responded to other therapies. Similarly, his research focuses on further developing deep brain stimulation therapies to diagnose and treat neurological conditions, including Parkinson's disease.

Little earned his medical degree at University College London. Remaining in London, he completed a residency in neurology at St. George's Hospital and the National Hospital for Neurology and Neurosurgery, then returned to University College London for a fellowship in neurology. He earned an MRCP(UK) – Membership of the Royal Colleges of Physicians of the United Kingdom – diploma in neurology. He also has a doctorate in experimental neurology from the University of Oxford.

  • Education

    UCL Medical School, MBBS, 2004

  • Residencies

    St. George's University Hospitals, Neurology, 2017

  • Fellowships

    UCL Medical School, Neurology, 2017

  • Academic Title

    Assistant Professor

I delight in working to combine excellent patient-facing holistic care with new cutting-edge technologies for treating movement disorders.

Where I see patients (1)

    My reviews


    Overall Experience
    136 Ratings
    About our process
    Nov 29, 2023
    Excellent bedside manner.
    Oct 29, 2023
    I always feel better when I see Dr. Little.
    Oct 12, 2023
    I never know whether or not I'm in the right place when I'm left waiting 15 to 20 minutes when the screen doesn't change at all after the initial greeting.
    Oct 10, 2023
    I am very pleased with Dr. Little's care.
    Sep 18, 2023
    Dr. Little is genuine very knowledgeable professional with whom my wife and I both felt comfortable and informed. He was/is efficient genuinely focused on taking care of my needs investigating my health issues and improving my health situation. I really feel his efforts to help me are helping and I look forward to working with him throughout my Parkinson's journey.
    Sep 15, 2023
    Care providers displayed their depth of knowledge and understanding the difficulties that the patient's facing.
    Sep 14, 2023
    Both MDs were caring informative great listeners and had a sense of humor- something very much an HCP asset.
    Sep 07, 2023
    My main reason for choosing UCSF is to be treated by MDs who are aware of the latest methods and medications Doctor Little is keeping up with the current research in the area that concerns me
    Jun 30, 2023
    Probably the best experience with a doctor in my lifeHe was very tuned in to the overall process..
    Jun 01, 2023
    Both Dr. Little and the fellow working with him (I wish I could remember her name) were exemplary. They were caring thorough patient patient and demonstrated a tremendous amount of empathy throughout the entire exam.
    May 13, 2023
    Very good
    Mar 27, 2023
    Dr. Little made me feel comfortable and was extremely professional while also giving me the feeling that he cared. He made sure to confirm that I understood my diagnosis and that he would now be my care provider going forward. He explained the programs that UCSF has available for future treatments that may help me. I left the office feeling very good about making the decision to come to UCSF and specifically about seeing Dr. Little.
    Mar 23, 2023
    Very professional informative
    Mar 11, 2023
    Dr. Little is brilliant and compassionate. He identified and explained my condition and provided a clear plan of treatment for me. His level of expertise was exceptional and he kindly answered all my questions. Highly recommend.
    Feb 05, 2023
    Dr Little is an outstanding caring provider
    Jan 27, 2023
    Excellent exam and care by entire team. Very impressive and helpful.
    Jan 09, 2023
    Dr Little is awesome! Can't say enough good things about him!
    Sep 08, 2022
    Very attentive and communicated easily via app
    Sep 03, 2022
    Jul 16, 2022
    I understand his decisions but I don't think he's taking my long experience with my body into account.
    Jun 09, 2022
    He is the fifth neurologist I have seen and the first one to correctly diagnose my disorders. He is kind he is patient he is supportive and he's brilliant
    Apr 29, 2022
    The clerk was not able to make the follow up appointment because she was new to her job and I was supposed to receive a call to make that appointment and so far after 24 hours I have not received a call. The follow up appointment is for three months and it's not late yet.
    Mar 19, 2022
    Dr Little was excellent.
    Feb 24, 2022
    He's amazing and I'm so grateful I found him. Fifth neurologist and the first one to diagnose my face
    Decorative Caduceus

    Understanding Motivation in Parkinson's Patients Through Neurophysiology

    Patients' responses on the tablet will be recorded in-clinic and at home. The investigators will tally their choices from the value-based decision making game (risky versus safe decisions) and report an average of risky responses.