Stephen Gluck, MD


Dr. Stephen Gluck is a nephrologist who cares for patients in the clinic as well as during hospitalization. He has expertise in a wide spectrum of kidney diseases, including inherited and genetic diseases as well as electrolyte disorders. He also treats patients in outpatient dialysis centers.

Gluck's research investigates certain specifics of renal function to promote a better understanding of disease processes.

Gluck earned his medical degree from the University of California, Los Angeles. He completed a residency in internal medicine at New York-Presbyterian/Columbia University Medical Center, where he later completed a fellowship in nephrology.

Gluck is a professor of medicine at UCSF.


Dialysis Center
1675 Scott Street
San Francisco, CA 94143-1617
Phone: (415) 885-7421
Fax: (415) 885-7396

Hours: Monday to Saturday
5 a.m. – 10 p.m.

Nephrology and Hypertension Faculty Practice
400 Parnassus Ave., B1 Plaza Level
San Francisco, CA 94143-0532
Phone: (415) 353-2507
Fax: (415) 353-2530

Hours: Monday to Friday
8 a.m. – 5 p.m.

Polycystic Kidney Disease (PKD) Center of Excellence
400 Parnassus Ave., B1 Plaza Level
San Francisco, CA 94143
Phone: (415) 514-2381

Hours: Monday to Friday,
9 a.m. - 5 p.m.

Academic Title


More about Stephen Gluck

Additional Languages



UCLA School of Medicine 1977


New York-Presbyterian/Columbia University Medical Center, Internal Medicine 1980


New York-Presbyterian/Columbia University Medical Center, Nephrology 1983

Selected Research and Publications

  1. Khalkhali-Ellis Z, Abbott DE, Bailey CM, Goossens W, Margaryan NV, Gluck SL, Reuveni M, Hendrix MJ. IFN-gamma regulation of vacuolar pH, cathepsin D processing and autophagy in mammary epithelial cells. J Cell Biochem. 2008 Sep 01; 105(1):208-18.
  2. Lu M, Ammar D, Ives H, Albrecht F, Gluck SL. Physical interaction between aldolase and vacuolar H+-ATPase is essential for the assembly and activity of the proton pump. J Biol Chem. 2007 Aug 24; 282(34):24495-503.
  3. Curtis LM, Gluck S. Distribution of Rab GTPases in mouse kidney and comparison with vacuolar H+-ATPase. Nephron Physiol. 2005; 100(3):p31-42.
  4. Sautin YY, Lu M, Gaugler A, Zhang L, Gluck SL. Phosphatidylinositol 3-kinase-mediated effects of glucose on vacuolar H+-ATPase assembly, translocation, and acidification of intracellular compartments in renal epithelial cells. Mol Cell Biol. 2005 Jan; 25(2):575-89.
  5. Gluck SL. Acid sensing in renal epithelial cells. J Clin Invest. 2004 Dec; 114(12):1696-9.
  6. Lu M, Sautin YY, Holliday LS, Gluck SL. The glycolytic enzyme aldolase mediates assembly, expression, and activity of vacuolar H+-ATPase. J Biol Chem. 2004 Mar 05; 279(10):8732-9.
  7. Chen SH, Bubb MR, Yarmola EG, Zuo J, Jiang J, Lee BS, Lu M, Gluck SL, Hurst IR, Holliday LS. Vacuolar H+-ATPase binding to microfilaments: regulation in response to phosphatidylinositol 3-kinase activity and detailed characterization of the actin-binding site in subunit B. J Biol Chem. 2004 Feb 27; 279(9):7988-98.
  8. Holliday LS, Welgus HG, Hanna J, Lee BS, Lu M, Jeffrey JJ, Gluck SL. Interstitial collagenase activity stimulates the formation of actin rings and ruffled membranes in mouse marrow osteoclasts. Calcif Tissue Int. 2003 Mar; 72(3):206-14.
  9. Lu M, Vergara S, Zhang L, Holliday LS, Aris J, Gluck SL. The amino-terminal domain of the E subunit of vacuolar H(+)-ATPase (V-ATPase) interacts with the H subunit and is required for V-ATPase function. J Biol Chem. 2002 Oct 11; 277(41):38409-15.
  10. Lu M, Holliday LS, Zhang L, Dunn WA, Gluck SL. Interaction between aldolase and vacuolar H+-ATPase: evidence for direct coupling of glycolysis to the ATP-hydrolyzing proton pump. J Biol Chem. 2001 Aug 10; 276(32):30407-13.
  11. Holliday LS, Lu M, Lee BS, Nelson RD, Solivan S, Zhang L, Gluck SL. The amino-terminal domain of the B subunit of vacuolar H+-ATPase contains a filamentous actin binding site. J Biol Chem. 2000 Oct 13; 275(41):32331-7.
  12. Holliday LS, Gluck SL, Slatopolsky E, Brown AJ. 1,25-Dihydroxy-19-nor-vitamin D(2), a vitamin D analog with reduced bone resorbing activity in vitro. J Am Soc Nephrol. 2000 Oct; 11(10):1857-64.
  13. Lee BS, Holliday LS, Krits I, Gluck SL. Vacuolar H+-ATPase activity and expression in mouse bone marrow cultures. J Bone Miner Res. 1999 Dec; 14(12):2127-36.
  14. Lee BS, Gluck SL, Holliday LS. Interaction between vacuolar H(+)-ATPase and microfilaments during osteoclast activation. J Biol Chem. 1999 Oct 08; 274(41):29164-71.
  15. Gluck SL, Lee BS, Wang SP, Underhill D, Nemoto J, Holliday LS. Plasma membrane V-ATPases in proton-transporting cells of the mammalian kidney and osteoclast. Acta Physiol Scand Suppl. 1998 Aug; 643:203-12.
  16. Niessen H, Meisenholder GW, Li HL, Gluck SL, Lee BS, Bowman B, Engler RL, Babior BM, Gottlieb RA. Granulocyte colony-stimulating factor upregulates the vacuolar proton ATPase in human neutrophils. Blood. 1997 Dec 01; 90(11):4598-601.
  17. Holliday LS, Welgus HG, Fliszar CJ, Veith GM, Jeffrey JJ, Gluck SL. Initiation of osteoclast bone resorption by interstitial collagenase. J Biol Chem. 1997 Aug 29; 272(35):22053-8.
  18. Bastani B, Underhill D, Chu N, Nelson RD, Haragsim L, Gluck S. Preservation of intercalated cell H(+)-ATPase in two patients with lupus nephritis and hyperkalemic distal renal tubular acidosis. J Am Soc Nephrol. 1997 Jul; 8(7):1109-17.
  19. Wax MB, Saito I, Tenkova T, Krupin T, Becker B, Nelson N, Brown D, Gluck SL. Vacuolar H+-ATPase in ocular ciliary epithelium. Proc Natl Acad Sci U S A. 1997 Jun 24; 94(13):6752-7.
  20. Bastani B, Gluck S. Adaptational changes in renal vacuolar H(+)-ATPase in the rat remnant kidney. J Am Soc Nephrol. 1997 Jun; 8(6):868-79.

Publications are derived from MEDLINE/PubMed and provided by UCSF Profiles, a service of the Clinical & Translational Science Institute (CTSI) at UCSF. Researchers can make corrections and additions to their publications by logging on to UCSF Profiles.