Tom Lue, MD


Dr. Tom Lue is an internationally recognized expert in the treatment of male sexual dysfunction at UCSF Medical Center. In 1983, he was one of the first urologists in the country to offer penile injection for erectile dysfunction. His research team proved that a new class of compound enhances erection in animals, which provided the scientific basis for three medications — Viagra, Levitra and Cialis, the most popular treatments for erectile dysfunction. Lue and his associates also developed the first animal model to study Peyronie's disease and introduced pentoxifylline for treatment.

Lue is vice chair of urology, medical director of the Knuppe Molecular Urology Laboratory and a professor of urology at UCSF. He graduated with highest honors from the Kaohsiung Medical College in Taiwan, completed urologic training at Downstate Medical Center in Brooklyn, N.Y. and was awarded the Valentine Fellowship from the New York Academy of Medicine to study the neurophysiology of the genitourinary tract at UCSF. He has won numerous awards, including the American Urological Association's Gold Cystoscope award and American Foundation of Urologic Disease's "Most Innovative Research Award." Lue has authored or co-authored more than 380 publications and 12 books on male sexual dysfunction.


Urology Practice
400 Parnassus Ave., Sixth Floor, Suite A610
San Francisco, CA 94143
Phone: (415) 353-2200
Fax: (415) 353-2641

Hours: Monday to Friday
8 a.m. – 5 p.m.

Conditions & Treatments

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Kaohsiung Medical College 1972


SUNY Downstate Medical Center, Urology 1981


UCSF Medical Center, Urology

Selected Research and Publications

  1. Wang B, Zhou J, Banie L, Reed-Maldonado AB, Ning H, Lu Z, Ruan Y, Zhou T, Wang HS, Oh BS, Wang G, Qi SL, Lin G, Lue TF. Low-intensity extracorporeal shock wave therapy promotes myogenesis through PERK/ATF4 pathway. Neurourol Urodyn. 2017 Aug 01.
  2. Reed-Maldonado AB, Kim JS, Lue TF. Avoiding complications: surgery for ischemic priapism. Transl Androl Urol. 2017 Aug; 6(4):657-665.
  3. Hudnall M, Reed-Maldonado AB, Lue TF. Advances in the understanding of priapism. Transl Androl Urol. 2017 Apr; 6(2):199-206.
  4. Lin G, Reed-Maldonado AB, Wang B, Lee YC, Zhou J, Lu Z, Wang G, Banie L, Lue TF. In Situ Activation of Penile Progenitor Cells With Low-Intensity Extracorporeal Shockwave Therapy. J Sex Med. 2017 Apr; 14(4):493-501.
  5. Wang B, Ning H, Reed-Maldonado AB, Zhou J, Ruan Y, Zhou T, Wang HS, Oh BS, Banie L, Lin G, Lue TF. Low-Intensity Extracorporeal Shock Wave Therapy Enhances Brain-Derived Neurotrophic Factor Expression through PERK/ATF4 Signaling Pathway. Int J Mol Sci. 2017 Feb 16; 18(2).
  6. Reed-Maldonado AB, Lue TF. The Current Status of Stem-Cell Therapy in Erectile Dysfunction: A Review. World J Mens Health. 2016 Dec; 34(3):155-164.
  7. Bushmakin AG, Cappelleri JC, Stecher V, Lue TF. Quantifying Barriers to Improvement of Treatment Satisfaction in Men With Erectile Dysfunction: Use of Person-Item Maps. J Sex Med. 2017 Jan; 14(1):152-159.
  8. Reed-Maldonado AB, Lue TF. Editorial Comment. Urology. 2017 Feb; 100:130.
  9. Lee YC, Lin G, Wang G, Reed-Maldonado A, Lu Z, Wang L, Banie L, Lue TF. Impaired contractility of the circular striated urethral sphincter muscle may contribute to stress urinary incontinence in female zucker fatty rats. Neurourol Urodyn. 2017 Aug; 36(6):1503-1510.
  10. Wang L, Lin G, Lee YC, Reed-Maldonado AB, Sanford MT, Wang G, Li H, Banie L, Xin Z, Lue TF. Transgenic animal model for studying the mechanism of obesity-associated stress urinary incontinence. BJU Int. 2017 Feb; 119(2):317-324.
  11. Reed-Maldonado AB, Lue TF. Re: A Meta-analysis of Extracorporeal Shock Wave Therapy for Peyronie's Disease. Eur Urol. 2016 Nov; 70(5):895-896.
  12. Lu Z, Lin G, Reed-Maldonado A, Wang C, Lee YC, Lue TF. Reply to Zi-Jun Zou, Jia-Yu Liang, Yi-Ping Lu's Letter to the Editor re: Zhihua Lu, Guiting Lin, Amanda Reed-Maldonado, Chunxi Wang, Yung-Chin Lee, Tom F. Lue. Low-intensity Extracorporeal Shock Wave Treatment Improves Erectile Function: A Systematic Review and Meta-analysis. Eur Urol 2017;71:223-33. Eur Urol. 2017 Feb; 71(2):e59-e60.
  13. Lin G, Reed-Maldonado AB, Lin M, Xin Z, Lue TF. Effects and Mechanisms of Low-Intensity Pulsed Ultrasound for Chronic Prostatitis and Chronic Pelvic Pain Syndrome. Int J Mol Sci. 2016 Jul 01; 17(7).
  14. Lu Z, Lin G, Reed-Maldonado A, Wang C, Lee YC, Lue TF. Low-intensity Extracorporeal Shock Wave Treatment Improves Erectile Function: A Systematic Review and Meta-analysis. Eur Urol. 2017 Feb; 71(2):223-233.
  15. Reed-Maldonado AB, Lue TF. Learning Penile Anatomy to Improve Function. J Urol. 2016 Sep; 196(3):643-4.
  16. Liu B, Lee YC, Alwaal A, Wang G, Banie L, Lin CS, Lin G, Lue TF. Carbachol-induced signaling through Thr696-phosphorylation of myosin phosphatase-targeting subunit 1 (MYPT1) in rat bladder smooth muscle cells. Int Urol Nephrol. 2016 Aug; 48(8):1237-1242.
  17. Lin G, Zhang H, Sun F, Lu Z, Reed-Maldonado A, Lee YC, Wang G, Banie L, Lue TF. Brain-derived neurotrophic factor promotes nerve regeneration by activating the JAK/STAT pathway in Schwann cells. Transl Androl Urol. 2016 Apr; 5(2):167-75.
  18. Reed-Maldonado AB, Lue TF. A syndrome of erectile dysfunction in young men? Transl Androl Urol. 2016 Apr; 5(2):228-34.
  19. Xin Z, Lin G, Lei H, Lue TF, Guo Y. Clinical applications of low-intensity pulsed ultrasound and its potential role in urology. Transl Androl Urol. 2016 Apr; 5(2):255-66.
  20. Cappelleri JC, Tseng LJ, Luo X, Stecher V, Lue TF. Simplified Interpretation of the Erectile Function Domain of the International Index of Erectile Function. J Sex Med. 2016 Apr; 13(4):690-6.

Publications are derived from MEDLINE/PubMed and provided by UCSF Profiles, a service of the Clinical & Translational Science Institute (CTSI) at UCSF. Researchers can make corrections and additions to their publications by logging on to UCSF Profiles.