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Anal Neoplasia Clinic, Research and Education (ANCRE) Center

The Anal Neoplasia Clinic, Research and Education (ANCRE) Center is the world's first clinic devoted to anal cancer prevention. UCSF experts were the first to identify the link between neoplasias (precancerous lesions) and anal cancer, and they remain global leaders in the field. The center is part of the UCSF Helen Diller Family Comprehensive Cancer Center.

Anal cancer is on the rise in the U.S., and the vast majority of cases are caused by human papillomavirus (HPV). This virus is extremely common among sexually active people and can lead to precancerous changes in the anal tissue, which may progress to anal cancer.

Most of the time, a healthy immune system can clear the virus. But particularly in immunocompromised people, certain strains of the virus can persist, increasing the risk of cancer. Our goal at the ANCRE Center is to provide the close monitoring and therapies that can reduce that risk.

Our center offers a wide range of screening, diagnostic and treatment options, including anal cytology, high-resolution anoscopy, anal biopsy, infrared coagulation therapy and electrocautery therapy. ANCRE’s doctors provide top-tier care as well as conducting research on anal neoplasia, giving our patients access to the latest and best techniques and therapies.

Our locations

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    Decorative Caduceus

    Collecting Blood and Tissue Sample Donations for Research for HIV/AIDS-Related Cancers

    The number of blood and tissue specimens will be counted.


    Decorative Caduceus

    Incidence of HIV Infection in Screening Indian Men Who Have Sex With Men

    The total number of participants with incident HIV divided by the total follow-up will be used to calculate the incidence per 100 person years. HIV status is determined by HIV rapid test and a confirmatory Western blot test.


    Decorative Caduceus

    Incidence of HPV Infection and HPV-Associated Disease in Screening Indian Men Who Have Sex With...

    The proportion of men with HPV 6, 11, 16, and/or 18-associated HGAIN will be calculated. HGAIN is determined by biopsy and HPV typing is based on concurrent DNA analysis of anal swabs.


    Decorative Caduceus

    Therapy Adapted for High Risk and Low Risk HIV-Associated Anal Cancer

    Evaluated by Common Terminology Criteria for Adverse Events (CTCAE) version 5.0. The adverse events will be summarized by overall, as well as by grade using frequency (percentage). A two-sided 95% confidence interval will be repor...


    Decorative Caduceus

    Nivolumab and Ipilimumab in Treating Patients With HIV Associated Relapsed or Refractory Classi...

    Will be defined as the starting dose level at which 1/6 subjects experience dose limiting toxicity (DLT) with the next higher dose having at least >= 2 participants encountering DLT. Toxicity data will be presented by type and sev...


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    • National Cancer Institute

      The National Cancer Institute has designated UCSF a comprehensive cancer center, its highest ranking. This designation is awarded to centers that demonstrate scientific excellence and the ability to conduct cancer research across many disciplines.

    • Commission on Cancer

      UCSF's cancer programs have been accredited by the American College of Surgeons' Commission on Cancer (CoC) since 1933. The CoC is a consortium of groups dedicated to improving cancer patients' survival and quality of life via research, education and better medical care.

    • National Comprehensive Cancer Network

      UCSF is a founding member of the National Comprehensive Cancer Network, an alliance of the world’s top cancer centers. The network brings together leaders in treatment and research to improve the quality, effectiveness and efficiency of cancer care.

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    Related clinics

    Center for Colorectal Surgery

    Bakar Precision Cancer Medicine Building

    See both of our San Francisco locations and learn about the center.

    Our research initiatives

    • UCSF Anal Cancer Research

      The UCSF Anal Neoplasia Clinic, Research and Education Center participates in research aimed at improving the understanding and treatment of anal neoplasia and cancer.

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      UCSF Helen Diller Family Comprehensive Cancer Center Research

      UCSF is home to a range of research initiatives aimed at improving outcomes for cancer patients everywhere. This includes research on topics such as immunotherapy, BRCA mutations and molecular diagnostic testing.

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