Prosthetic Replacement of the Ocular Surface Ecosystem (PROSE) Clinic

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Prosthetic replacement of the ocular surface ecosystem (PROSE) is a pioneering, FDA-approved treatment that can restore vision, support healing, reduce irritative symptoms and improve quality of life for patients with complex corneal disease, especially those for whom conventional treatments have failed. The UCSF PROSE Clinic is only one of two PROSE providers in the western United States and is among approximately 16 centers world-wide. PROSE devices are fit only at major medical centers with expertise in treating complex corneal disease and are manufactured at only one site in the world, the Boston Foundation for Sight.

Patients with conditions such as dry eye syndrome, keratoconus, Stevens-Johnson syndrome, chronic ocular graft-versus-host disease (GVHD), Sjögren's syndrome, pellucid marginal degeneration, ocular trauma, complications of LASIK, or complications of cornea transplantation can benefit from PROSE. The treatment offers continued benefit, as defined by improved visual function and continued device wear at five years, to almost 75% of candidates with complex corneal disease.

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PROSE devices are transparent domes, about the size of a nickel, made of gas-permeable plastic that allows oxygen to reach the ocular surface. PROSE devices fit under the eyelids and rest on the sclera (the relatively insensitive white tissue) of the eye, vaulting the damaged cornea and creating a new smooth optical surface that protects the eye from the environment and blink trauma. The devices used in PROSE are filled with sterile saline at the time of insertion, creating a reservoir of fluid that continuously bathes the ocular surface with oxygenated artificial tears. PROSE doctors design and fit devices to each patient's unique eye shape and to meet specific treatment goals.

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Getting Here

PROSE Clinic
Beckman Vision Center
533 Parnassus Ave, Fifth floor
San Francisco, CA 94143
Phone: (415) 353-2177
Fax: (415) 476-9281

Hours: Monday to Friday, 8 a.m. - 5 p.m.

What to Bring

    New patients should bring in any type of contact lenses that they are wearing. Some patients may need to spend the whole day in clinic so a book may be helpful.

Access Your Health Information Online

This clinic uses UCSF MyChart, an online patient service. Message your provider, request medication refills, view some test results and more.

Learn more about UCSF MyChart

Research and Clinical Trials


Parking at Parnassus

Public parking for an hourly fee at UCSF Medical Center is available in the seven-level Millberry Union Garage at 500 Parnassus Ave. There are two garage entrances — one on the north side of Parnassus Avenue and another on Irving Street, just east of Third Avenue.

Another garage with an hourly fee, at 350 Parnassus Ave., is open Monday to Friday from 6 a.m. to 10 p.m.

Metered street parking is rarely available.

Patients being admitted to the hospital may be dropped off at the circular driveway leading to the main entrance at 505 Parnassus Ave. This area also may be used to pick up patients who are being discharged.

For more information about parking at Parnassus, call Campus Parking Services at 476-2566.

Valet Parking Service

Valet parking service is available at the Ambulatory Care Center (ACC) at 400 Parnassus Ave. from 8 a.m. to 3 p.m. The valet service is free but patients must pay regular parking fees. For more information about the valet service, call (415) 476-6200.

A UCSF "greeter" also is available at the ACC from 8 a.m. to 5 p.m. to assist patients find their way.

Public Transportation


UCSF Medical Center is accessible via Muni streetcar line N-Judah*, which stops at Second Avenue and Irving Street, and the following Muni bus lines, which stop in front of the hospital:

  • 43-Masonic*
  • 6-Parnassus

For more information about Muni visit,

* Wheelchair accessible bus routes


To download a referral form: UCSF PROSE Referral form