Hereditary Cancer Clinic

The UCSF Hereditary Cancer Clinic offers patients and families with genetic mutations linked to hereditary cancers – such as mutations of the BRCA gene – personalized care and planning for their long-term health. Our services include:

  • Genetic counseling and testing for patients and families
  • Coordination of follow-up care, including cancer prevention and surveillance, with referrals to other specialty clinics at UCSF as needed

The clinic is part of the UCSF Center for BRCA Research. Our team of clinicians and investigators is dedicated to developing new treatments, improving patient outcomes and survival rates, and providing more personalized care to families who carry mutations linked to hereditary cancers.

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What to Expect

If you have never had genetic testing, the genetic counselor will review your family history and share information about hereditary cancer. Your counselor will discuss the potential benefits and limitations of genetic testing and help you consider these, along with your medical and personal factors. If you decide to have genetic testing, the counselor will arrange it for you.

We will collect a blood or saliva sample and send it to a specialized laboratory where it will be tested for the hereditary cancer mutation. In some cases, based on your personal and family medical history, the genetic counselor may recommend additional testing.

If you have previously had a genetic test showing a mutation, the genetic counselor will review any new questions you have, share recent advances relevant to your situation, and review current recommendations for cancer monitoring and prevention. This is also a good opportunity to consider whether you have relatives who have not been tested and might also benefit from testing.

Our knowledge of and recommendations for hereditary cancer are changing quickly as the research evolves. We invite all our patients to enroll in a long-term follow-up protocol that will allow us to use your information anonymously in research on hereditary cancer. Through this protocol, we will periodically send you updates about advances in hereditary cancer and also request occasional updates from you about your family. Your genetic counselor can tell you more about this and other research opportunities during your appointment.

Before Your Appointment

Please send us a copy of any original genetic test reports for you or your family members. If you have difficulty getting the original report, our assistant can help you.

We will email you a link to a family history questionnaire, or if you prefer, we can mail you a paper copy. Please complete the questionnaire before your appointment.

Our locations

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    Decorative Caduceus

    APL-101 Study for NSCLC With c-Met EXON 14 Skip Mutations and c-Met Dysregulation Advance Solid...

    The primary Phase 1 purpose of this study is to assess overall safety and tolerability and recommended Phase 2 dose (RP2D) of APL-101. The Phase 2 portion will assess efficacy of the dose determined in phase 1 in i...

    Recruiting

    Decorative Caduceus

    AO-176 in Multiple Solid Tumor Malignancies

    This is a first-in-human, Phase 1 multi-center, open-label, dose escalation and expansion study of AO-176 which will evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics, and clinical effects of...

    Recruiting

    Decorative Caduceus

    Safety and Efficacy of MAK683 in Adult Patients With Advanced Malignancies

    The purpose of this Phase I/II study is to establish the maximum tolerated dose (MTD) and/or recommended phase 2 dose (RP2D) and to evaluate the safety, antitumor activity and pharmacokinetic (PK) profile of MAK683 i...

    Recruiting

    Decorative Caduceus

    Rucaparib and Irinotecan in Cancers With Mutations in DNA Repair

    This is an open label, non-randomized, dose escalation and expansion Phase Ib trial to evaluate the safety and recommended phase II dose of the combination of irinotecan and rucaparib.

    Recruiting

    Decorative Caduceus

    A Study of LY3200882 in Participants With Solid Tumors

    The main purpose of this study is to evaluate the safety of the study drug known as LY3200882 in participants with solid tumors.

    Recruiting

    Decorative Caduceus

    Phase Ib Study of Alpelisib With Cisplatin in Patients With HPV+ Solid Tumor Malignancies

    This phase Ib trial studies the best dose and side effects of alpelisib and cisplatin in treating patients with human papillomavirus (HPV) positive solid tumor malignancies. Alpelisib may stop the growth of tumor cel...

    Recruiting

    Decorative Caduceus

    A Study Evaluating MM-310 in Patients With Solid Tumors

    MM-310 is a liposomal formulation of a docetaxel prodrug that targets the EphA2 receptor on cancer cells. Docetaxel is an approved chemotherapeutic drug.This study is a Phase 1 open-label study of MM-310 in patients ...

    Recruiting

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    • n8-2x

      Ranked No. 12 in the nation for cancer care

    • NIH-2x

      Designated comprehensive cancer center

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    What to Bring

    • Photo I.D.
    • Health insurance card
    • Insurance authorization, if required
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    • Recent test results related to your condition
    • List of your medications, including dosages, plus any you're allergic to
    • List of questions you may have
    • Device or paper for taking notes

    Related clinics

    Cancer Survivorship and Wellness Institute

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    Our research initiatives

    • UCSF-Center-for-BRCA-Research-2x

      UCSF Center for BRCA Research

      The UCSF Center for BRCA Research is working to discover which types of cancer – beyond breast and ovarian cancers – may be associated with mutations in the BRCA genes, and whether other factors impact risk.

    • UCSF-Helen-Diller-Family-Comprehensive-Cancer-Center-Research-2x

      UCSF Helen Diller Family Comprehensive Cancer Center Research

      UCSF is home to a range of research initiatives aimed at improving outcomes for cancer patients everywhere. This includes research on topics such as immunotherapy, BRCA mutations and molecular diagnostic testing.

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