Hereditary Cancer Clinic

The UCSF Hereditary Cancer Clinic offers patients and families with genetic mutations linked to hereditary cancers – such as mutations of the BRCA gene – personalized care and planning for their long-term health. Our services include:

  • Genetic counseling and testing for patients and families
  • Coordination of follow-up care, including cancer prevention and surveillance, with referrals to other specialty clinics at UCSF as needed

The clinic is part of the UCSF Center for BRCA Research. Our team of clinicians and investigators is dedicated to developing new treatments, improving patient outcomes and survival rates, and providing more personalized care to families who carry mutations linked to hereditary cancers.

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What to Expect

If you have never had genetic testing, the genetic counselor will review your family history and share information about hereditary cancer. Your counselor will discuss the potential benefits and limitations of genetic testing and help you consider these, along with your medical and personal factors. If you decide to have genetic testing, the counselor will arrange it for you.

We will collect a blood or saliva sample and send it to a specialized laboratory where it will be tested for the hereditary cancer mutation. In some cases, based on your personal and family medical history, the genetic counselor may recommend additional testing.

If you have previously had a genetic test showing a mutation, the genetic counselor will review any new questions you have, share recent advances relevant to your situation, and review current recommendations for cancer monitoring and prevention. This is also a good opportunity to consider whether you have relatives who have not been tested and might also benefit from testing.

Our knowledge of and recommendations for hereditary cancer are changing quickly as the research evolves. We invite all our patients to enroll in a long-term follow-up protocol that will allow us to use your information anonymously in research on hereditary cancer. Through this protocol, we will periodically send you updates about advances in hereditary cancer and also request occasional updates from you about your family. Your genetic counselor can tell you more about this and other research opportunities during your appointment.

Before Your Appointment

Please send us a copy of any original genetic test reports for you or your family members. If you have difficulty getting the original report, our assistant can help you.

We will email you a link to a family history questionnaire, or if you prefer, we can mail you a paper copy. Please complete the questionnaire before your appointment.

Our locations

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    Decorative Caduceus

    A Phase 1/2, Study Evaluating the Safety, Tolerability, PK, and Efficacy of AMG 510 in Subjects...

    Evaluate the safety and tolerability of AMG 510 in adult subjects with KRAS p.G12C mutant advanced solid tumors. Estimate the maximum tolerated dose (MTD) and/or a recommended phase 2 dose (RP2D) in adult su...


    Decorative Caduceus

    Efficacy and Safety of Olaparib (MK-7339) in Participants With Previously Treated, Homologous R...

    This study will evaluate the efficacy and safety of olaparib (MK-7339) monotherapy in participants with multiple types of advanced cancer (unresectable and/or metastatic) that: 1) have progressed or been intolerant t...


    Decorative Caduceus

    9-ING-41 in Patients With Advanced Cancers

    GSK-3β is a potentially important therapeutic target in human malignancies. The Actuate 1801 Phase 1/2 study is designed to evaluate the safety and efficacy of 9-ING-41, a potent GSK-3β inhibitor, as a single agent a...


    Decorative Caduceus

    Study of ORIC-101 in Combination With Anticancer Therapy

    The purpose of this study is to establish the recommended Phase 2 dose (RP2D), safety, pharmacokinetics (PK), pharmacodynamics (PD), and preliminary antitumor activity of ORIC-101 in combination with other anticancer...


    Decorative Caduceus

    AO-176 in Multiple Solid Tumor Malignancies

    This is a first-in-human, Phase 1 multi-center, open-label, dose escalation and expansion study of AO-176 which will evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics, and clinical effects of...


    Decorative Caduceus

    Safety and Efficacy of MAK683 in Adult Patients With Advanced Malignancies

    The purpose of this Phase I/II study is to establish the maximum tolerated dose (MTD) and/or recommended phase 2 dose (RP2D) and to evaluate the safety, antitumor activity and pharmacokinetic (PK) profile of MAK683 i...


    Decorative Caduceus

    Rucaparib and Irinotecan in Cancers With Mutations in DNA Repair

    This is an open label, non-randomized, dose escalation and expansion Phase Ib trial to evaluate the safety and recommended phase II dose of the combination of irinotecan and rucaparib.


    Awards & recognition

    • usnews-neurology

      Best hospital in Northern California

    • n8-2x

      Ranked No. 12 in the nation for cancer care

    • NIH-2x

      Designated comprehensive cancer center

    Support services

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    Restorative Movement Class

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    Spa Infusion

    Pamper yourself while fighting cancer. Free treatments for patients receiving chemotherapy at our Mount Zion campus include massage, acupressure and more.

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    Preparing for your appointment

    What to Bring

    • Photo I.D.
    • Health insurance card
    • Insurance authorization, if required
    • Doctor's referral, if required
    • Recent test results related to your condition
    • List of your medications, including dosages, plus any you're allergic to
    • List of questions you may have
    • Device or paper for taking notes

    Related clinics

    Cancer Survivorship and Wellness Institute

    Bakar Precision Cancer Medicine Building

    1600 Divisadero St., Fourth Floor
    San Francisco, CA 94115

    Our research initiatives

    • UCSF-Center-for-BRCA-Research-2x

      UCSF Center for BRCA Research

      The UCSF Center for BRCA Research is working to discover which types of cancer – beyond breast and ovarian cancers – may be associated with mutations in the BRCA genes, and whether other factors impact risk.

    • UCSF-Helen-Diller-Family-Comprehensive-Cancer-Center-Research-2x

      UCSF Helen Diller Family Comprehensive Cancer Center Research

      UCSF is home to a range of research initiatives aimed at improving outcomes for cancer patients everywhere. This includes research on topics such as immunotherapy, BRCA mutations and molecular diagnostic testing.

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