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Cancer Clinical Trials & Investigational Treatments Center

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(415) 885-7796

The UCSF Cancer Clinical Trials and Investigational Treatments Center offers patients with advanced cancer the opportunity to participate in the trials testing new, cutting-edge treatments for the first time in humans. These studies are known as early phase, or phase I, clinical trials. Our center is open to patients with solid tumor cancers, including breast, pancreatic, colorectal, prostate, lung and gynecologic cancers.

Our program brings together leading physician-scientists and other researchers who are at work on more effective, less toxic cancer treatments. These may be new medications; novel treatment combinations; or innovative approaches, such as targeted therapies that attack the tumor without damaging healthy cells. Patients who volunteer for these clinical trials may be the first to benefit from a pioneering therapy.

Our program is part of the UCSF Helen Diller Family Comprehensive Cancer Center, which the National Cancer Institute has designated a comprehensive cancer center since 1999. This designation recognizes centers committed to both pursuing needed research and providing full services to patients with cancer. As such a center, we have numerous early phase clinical trials that are recruiting patients with advanced cancers.

While our center is currently limited to early phase trials, UCSF has a robust clinical trials program that includes later phase studies in most types of cancer. To learn about available trials, please call (877) 827-3222, email [email protected] or search our database of clinical cancer trials at UCSF.

Learn more about clinical trials and how they work.

Our locations

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    Decorative Caduceus

    Pembrolizumab and Tamoxifen With or Without Vorinostat for the Treatment of Estrogen Receptor P...

    Will be defined as the proportion of participants randomized to that arm whose status is stable disease (SD) or better (complete response (CR), partial response (PR)). The observed ORR will be compared to the respective null (inef...


    Decorative Caduceus

    Apalutamide Plus Cetrelimab in Patients With Treatment-Emergent Small Cell Neuroendocrine Prost...

    The composite response rate is determined by a combination of a decline from baseline in serum PSA of >= 50%, confirmed by repeat measurement ≥ 4 weeks later (PSA50) AND/OR a complete response (CR) or partial response (PR) as dete...


    Decorative Caduceus

    ZEN-3694, Enzalutamide, and Pembrolizumab for the Treatment of Metastatic Castration-Resistant ...

    Defined as either objective response per Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 criteria (complete response (CR), partial response (PR)) or confirmed >= 50% decline from serum prostate-specific antigen (PSA) at ...


    Decorative Caduceus

    Phase I Tolerability, Efficacy, and Safety Study of Pazopanib in Combination With PCI-24781 in ...

    A dose limiting toxicity (DLT) will be defined as any predetermined adverse events occurring during Cycle 1 when association to therapy that is part of this study is related or possibly related


    Decorative Caduceus

    Apalutamide With or Without Stereotactic Body Radiation Therapy in Treating Participants With C...

    The primary endpoint for the study is the proportion of patients with undetectable serum PSA (< 0.2 ng/mL) at 6 months following completion of apalutamide therapy (18 months from date of randomization). Patients who discontinue ap...


    Decorative Caduceus

    68Ga-PSMA-11 PET for the Diagnosis of Metastatic Castration Resistant Prostate Cancer

    The mean SUVmax and standard deviation across the primary tumor and the 5 largest lesions in each of three metastatic sites (nodal, visceral and osseous; for a maximum of 16 lesions per patient) will be descriptively reported.


    Decorative Caduceus

    Dose Escalation of RMC-5552 Monotherapy in Relapsed/Refractory Solid Tumors

    Incidence, nature, and severity of treatment-emergent AEs and serious AEs, including incidence and severity of findings in laboratory values or vital signs for RMC-5552 monotherapy


    Decorative Caduceus

    Phase II Trial of AZD6738 Alone and in Combination With Olaparib

    On overall response will be reported as a percentage of participants with a complete response (CR) or partial response (PR) as measured by the Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1


    Decorative Caduceus

    9-ING-41 in Patients With Advanced Cancers

    The standard assessments used to assign a score to any affected organ system as per the NCI CTCAE 4.03 will be conduced at each protocol-specified timepoint.


    Decorative Caduceus

    APL-101 Study of Subjects With NSCLC With c-Met EXON 14 Skip Mutations and c-Met Dysregulation ...

    Adverse events, serious adverse events, and dose limiting toxicities


    Awards & recognition

    • usnews-neurology

      Among the top hospitals in the nation

    • Best in Northern California for cancer care (tie)

    Accreditations & memberships

    • National Cancer Institute

      The National Cancer Institute has designated UCSF a comprehensive cancer center, its highest ranking. This designation is awarded to centers that demonstrate scientific excellence and the ability to conduct cancer research across many disciplines.

    • Commission on Cancer

      UCSF's cancer programs have been accredited by the American College of Surgeons' Commission on Cancer (CoC) since 1933. The CoC is a consortium of groups dedicated to improving cancer patients' survival and quality of life via research, education and better medical care.

    • National Comprehensive Cancer Network

      UCSF is a founding member of the National Comprehensive Cancer Network, an alliance of the world’s top cancer centers. The network brings together leaders in treatment and research to improve the quality, effectiveness and efficiency of cancer care.

    Support services

    Support Group

    Art for Recovery

    Creativity can help people with serious illnesses cope, heal and express what they're going through. Find out about our program and how to join.


    Cancer Exercise Counseling

    Our one-on-one exercise training sessions, customized for your needs and abilities, can complement other cancer treatments and speed your recovery.

    Patient Resource

    Cancer Nutrition Counseling

    UCSF Health offers free nutrition counseling to our patients with cancer, as well as nutrition seminars that are open to anyone. Learn more.

    Support Group

    Cancer Support Groups

    These groups offered by the Ida and Joseph Friend Patient and Family Cancer Support Center are free and available to all patients, whether or not you get your health care at UCSF.


    Core & More Class for Cancer Patients

    A strong body helps you fight cancer and enjoy life. Join this class to stabilize your core, strengthen your muscles and improve overall fitness. For cancer patients and caregivers!

    Patient Resource

    Friend to Friend Specialty Shops

    A one-stop boutique for patients with cancer. Get professional help with wigs, prostheses, sun-protective clothing, makeup, skin care and more.


    Meditation & Guided Imagery for Cancer Patients

    Drop in for a free class designed to help you heal, relax and find balance during your treatment. UCSF and non-UCSF patients are welcome.

    Patient Resource

    Oncology Social Work

    Social workers offer support, problem-solving, help accessing UCSF cancer-related resources and more. Find out how to contact the social worker for your clinic.

    Patient Resource

    Patient & Family Cancer Support Center

    The center offers wellness programming, community, support groups, classes, workshops and more at no cost to people facing cancer and their loved ones.

    Support Group

    Peer Support Programs for Cancer

    Patients are matched with peer support volunteers according to criteria such as diagnosis, cancer stage, age or gender. Speak to someone who's "been there."

    Preparing for your appointment

    What to Bring

    • Photo I.D.
    • Health insurance card
    • Insurance authorization, if required
    • Doctor's referral, if required
    • Recent test results related to your condition
    • List of your medications, including dosages, plus any you're allergic to
    • List of questions you may have
    • Device or paper for taking notes

    International Services

    If you live outside the United States and are coming to UCSF for medical treatment, our patient liaisons can help coordinate all aspects of your visit.

    Learn more

    Interpreting Services

    UCSF offers interpreters in various languages, including American Sign Language (ASL), as well as services for deaf, hard-of-hearing and visually impaired patients.

    Learn more

    Hospital Stays

    Make your hospital stay as smooth and comfortable as possible by finding out how to prepare and what to expect.

    Learn more

    Your Doctor Visit

    See our top 10 tips for making your UCSF doctor’s appointment as stress-free and productive as possible.

    Learn more

    Related clinics

    Breast Care Center

    Berkeley Outpatient Center

    3100 San Pablo Ave., Suite 280
    Berkeley, CA 94702

    Pancreas Center

    Bakar Precision Cancer Medicine Building

    1825 Fourth St., Fourth Floor
    San Francisco, CA 94158

    Center for Colorectal Surgery

    Bakar Precision Cancer Medicine Building

    See both of our San Francisco locations and learn about the center.

    Prostate Cancer Center

    Bakar Precision Cancer Medicine Building

    1825 Fourth St., Sixth Floor
    San Francisco, CA 94158

    Lung Cancer Screening Program

    185 Berry St., Lobby 6, Suite 190
    San Francisco, CA 94107

    Gynecologic Oncology Center

    Bakar Precision Cancer Medicine Building

    See all 3 of our Bay Area locations and learn more about the center.

    Our research initiatives

    • Athena-Breast-Health-Network-2x

      Athena Breast Health Network

      The Athena Breast Health Network, a collaborative organization that includes UCSF, promotes data sharing to help all partners deliver more effective and personalized care to patients with breast cancer.

    • breast-cancer-trials-2x

      Breast Cancer Trials helps match patients who want to participate in breast cancer research with open studies that are right for them.

    • UCSF-Helen-Diller-Family-Comprehensive-Cancer-Center-Research-2x

      UCSF Helen Diller Family Comprehensive Cancer Center Research

      UCSF is home to a range of research initiatives aimed at improving outcomes for cancer patients everywhere. This includes research on topics such as immunotherapy, BRCA mutations and molecular diagnostic testing.

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    UCSF Help Center

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