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Hematology, Blood & Marrow Transplant, and Cellular Therapy (HBC) Program

The UCSF Hematology, Blood and Marrow Transplant, and Cellular Therapy (HBC) Program provides advanced treatment options with care and compassion. Our acclaimed program draws patients from around the world seeking effective, innovative therapies from specialists in blood disorders, including blood cancers.

UCSF is also home to a robust research program for hematology, bone marrow transplant and immunotherapy. Patients may have the option to participate in clinical trials (studies of promising new treatments), including those evaluating cutting-edge immunotherapies, such as tumor vaccines or CAR T-cell therapy.

CAR T-cell therapy

The UCSF patient care and research teams are globally recognized for their groundbreaking work in cell-based immunotherapy for cancer. In 2011, our researchers made history by developing and testing ipilimumab (Yervoy), the first checkpoint inhibitor to be approved by the Food and Drug Administration (FDA). We continue as leaders in the field by actively engaging in CAR T-cell treatment and research.

FDA-approved CAR T-cell therapy uses the patient's own immune system to fight certain cancers. This one-time treatment is used when the cancer has resisted all other therapeutic options or recurred more than once.

Many patients have achieved long-term remission (decrease or disappearance of symptoms) through CAR T-cell therapy. These include patients with B-cell non-Hodgkin's lymphoma, B-cell acute lymphoblastic leukemia and mantle cell lymphoma. Research is ongoing to evaluate CAR T-cell therapy for treating other blood cancers, including multiple myeloma, and solid tumors of the breast, prostate, brain, lungs and other organs.

Comprehensive cancer care

A cancer diagnosis and the treatment that follows can be overwhelming, both physically and emotionally. We're committed to supporting patients and their caregivers throughout their cancer journeys.

UCSF Helen Diller Family Comprehensive Cancer Center

As part of the UCSF Helen Diller Family Comprehensive Cancer Center, the UCSF Patient and Family Cancer Support Center offers access to many services, including:

Parker Institute for Cancer Immunotherapy

Our program is a collaborator in the Parker Institute for Cancer Immunotherapy, an organization comprising 10 of the world's leading cancer centers. The Parker Institute's mission is to turn cancer into a curable disease by accelerating the development of breakthrough immunotherapies.

Our locations

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    Our team

    Decorative Caduceus

    A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (C...

    The primary objective of this access and distribution protocol is to examine the incidence of neutrophil recovery of ≥500/mm3 after cord blood transplantation in a multi-institution setting using CBUs that are not FDA licensed.

    Recruiting

    Decorative Caduceus

    P-BCMA-ALLO1 Allogeneic CAR-T Cells in the Treatment of Subjects With Multiple Myeloma

    Rate of dose limiting toxicities (DLT)

    Recruiting

    Decorative Caduceus

    Testing Drug Treatments After CAR T-cell Therapy in Patients With Relapsed/Refractory Diffuse L...

    Will compare PFS in participants with relapsed/refractory large B-cell lymphoma or follicular lymphoma grade 3B with stable disease (SD) or partial remission (PR) on first imaging response (day +30 positron emission tomography [PE...

    Recruiting

    Decorative Caduceus

    Molecular Evaluation of AML Patients After Stem Cell Transplant to Understand Relapse Events

    Overall survival post-alloHCT via comparison between those testing positive or negative using an optimized molecular monitoring approach.

    Recruiting

    Decorative Caduceus

    Talquetamab in Combination With Iberdomide and Dexamethasone for Relapsed or Refractory Multipl...

    Safety will be evaluated for the population of participants who received at least one dose of study drug. Treatment-emergent AEs will be graded by the Common Terminology Criteria for Adverse Events (CTCAE) version 5.0.

    Recruiting

    Decorative Caduceus

    Glofitamab With Pirtobrutinib for Relapsed or Refractory Mantle Cell Lymphoma

    The severity of the toxicities will be graded according to the National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events (CTCAE) version (v)5.0. AEs and clinically significant laboratory abnormalities meeting ...

    Recruiting

    Decorative Caduceus

    Venetoclax, Daratumumab, and Dexamethasone for Systemic Light-Chain Amyloidosis With Translocat...

    A dose limiting toxicity (DLT) will be defined as an adverse event that are considered by the investigator to be at least possibly related to the study drugs and are observed within the DLT assessment window (Cycle 1, Days 1 to 28...

    Recruiting

    Decorative Caduceus

    Ruxolitinib With De-Intensified HLH-94 for the Treatment of Hemophagocytic Lymphohistiocytosis ...

    The proportion of responder (complete response (CR) or partial response (PR)) or non-responder at the end of induction using a physician developed response criteria will be reported. Those with non-malignant HLH (nmHLH) will be as...

    Recruiting

    Decorative Caduceus

    IO-202 as Monotherapy and IO-202 Plus Azacitidine ± Venetoclax in Patients in AML and CMML

    Incidence of adverse events

    Recruiting

    Decorative Caduceus

    Study of Biomarker-Based Treatment of Acute Myeloid Leukemia

    The feasibility of completing molecular, genetic, immunophenotypic, and biochemical testing for assignment of therapy will be assessed based on the proportion of patients for whom testing is completed within 7 days of the registra...

    Recruiting

    Rankings & achievements

    • usnews-neurology

      Among the top hospitals in the nation

    • Best in Northern California and No. 7 in the nation for cancer care

    • Rated high-performing hospital for leukemia, lymphoma & myeloma care

    • 220-2x

      blood and marrow transplants performed each year

    • 1986-2x

      Founded in 1986

    Accreditations & memberships

    • National Cancer Institute

      The National Cancer Institute has designated UCSF a comprehensive cancer center, its highest ranking. This designation is awarded to centers that demonstrate scientific excellence and the ability to conduct cancer research across many disciplines.

    • Commission on Cancer

      UCSF's cancer programs have been accredited by the American College of Surgeons' Commission on Cancer (CoC) since 1933. The CoC is a consortium of groups dedicated to improving cancer patients' survival and quality of life via research, education and better medical care.

    • National Comprehensive Cancer Network

      UCSF is a founding member of the National Comprehensive Cancer Network, an alliance of the world’s top cancer centers. The network brings together leaders in treatment and research to improve the quality, effectiveness and efficiency of cancer care.

    • FACT Accreditation

      Our Hematology, BMT and Cellular Therapy Program is accredited by the Foundation for Accreditation of Cellular Therapy (FACT). FACT-accredited programs follow specific high-quality medical and laboratory processes when providing cellular therapies such as BMT.

    Patient education

    Hematology and BMT Resource Guide

    This hematology and bone marrow transplant (BMT) resource guide provides information about diseases and treatments, employment, insurance and more.

    Autologous Transplant Guide

    Having a blood and marrow transplant (BMT) is a difficult experience. Read this guide to help prepare you and your family and book an appointment today.

    Matched Unrelated Donor Transplantation

    Bone marrow transplantation can be performed using one's own bone marrow or by using another person's bone marrow. Learn more here.

    Support services

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    Patient Resource

    Case Management & Social Work

    Connect with a team that can help you find resources, solve problems and advocate for you during treatment at UCSF.

    Patient Resource

    Kôz Hospitality House

    Kôz Hospitality House provides comfortable, reasonably priced accommodations near our Parnassus campus for UCSF patients during their treatment.

    Class

    Mindfulness-Based Stress Reduction Class

    This eight-week class teaches mindfulness practices that can reduce stress and improve your overall health, such as meditation and body awareness.

    Patient Resource

    Patient Relations

    We welcome feedback about your experience at UCSF Health. Find out how to contact us with comments, questions or concerns.

    Patient Resource

    Spiritual Care Services

    Chaplains representing many faiths are available around the clock to provide support, comfort and counsel to patients, families and caregivers.

    Preparing for your appointment

    What to Bring

    • Photo I.D.
    • Health insurance card
    • Insurance authorization, if required
    • Doctor's referral, if required
    • Recent test results related to your condition
    • List of your medications, including dosages, plus any you're allergic to
    • List of questions you may have
    • Device or paper for taking notes

    International Services

    If you live outside the United States and are coming to UCSF for medical treatment, our patient liaisons can help coordinate all aspects of your visit.

    Learn more

    Interpreting Services

    UCSF offers interpreters in various languages, including American Sign Language (ASL), as well as services for deaf, hard-of-hearing and visually impaired patients.

    Learn more

    Hospital Stays

    Make your hospital stay as smooth and comfortable as possible by finding out how to prepare and what to expect.

    Learn more

    Your Doctor Visit

    See our top 10 tips for making your UCSF doctor’s appointment as stress-free and productive as possible.

    Learn more

    Related clinics

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    Cancer Immunotherapy Toxicity Evaluation (CITE) Program

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    Cancer Symptom Management

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    Cancer Center Redwood City

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    San Mateo, CA 94402

    Psycho-Oncology

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    1825 Fourth St.
    San Francisco, CA 94158

    UCSF-John Muir Health Cancer Center in Berkeley

    Berkeley Outpatient Center

    3100 San Pablo Ave., Suite 280
    Berkeley, CA 94702

    Our research initiatives

    • UCSF-Helen-Diller-Family-Comprehensive-Cancer-Center-Research-2x

      UCSF Helen Diller Family Comprehensive Cancer Center Research

      UCSF is home to a range of research initiatives aimed at improving outcomes for cancer patients everywhere. This includes research on topics such as immunotherapy, BRCA mutations and molecular diagnostic testing.

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    UCSF Help Center

    (888) 689-8273

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