Hematology, Blood & Marrow Transplant, and Cellular Therapies (HBC)

The UCSF Hematology, Blood and Marrow Transplant, and Cellular Therapy (HBC) Program is dedicated to providing patients with the most advanced and innovative treatment options, along with compassionate and personalized care. People from throughout the United States and abroad choose our program for its groundbreaking work and for our providers, who specialize in blood disorders and the use of transplantation and cellular therapy.

UCSF is also home to a robust research program. Patients may have the option to participate in novel clinical trials, including studies evaluating the use of targeted therapeutics, new transplantation techniques and immunotherapy treatments, such as tumor vaccines and CAR T-cell therapy.

CAR T-Cell Therapy

CAR T-cell therapy – which uses the patient’s immune system to fight cancer cells – has dramatically changed how blood cancers are treated. Our clinical and research teams are internationally renowned for their pioneering work in cell-based immunotherapy for cancer, and we have been at the forefront of designing new CAR T-cell strategies for treating blood cancers. UCSF was one of the first institutions licensed to offer standard-of-care CAR T cells for young patients with acute lymphocytic leukemia (ALL).

We now offer FDA-approved CAR T-cell therapy to patients with ALL, patients with various forms of non-Hodgkin’s lymphoma, and patients with relapsed and refractory multiple myeloma. Even after resisting all other treatment options or relapsing after standard treatment, those conditions have responded dramatically to CAR T-cell therapy.

In patients with B-cell non-Hodgkin’s lymphoma, B-cell acute lymphoblastic leukemia and mantle cell lymphoma (MCL), CAR T-cell therapy has resulted in long-term remissions and even cures for some. Research is ongoing to increase the number of patients cured and expand the use of CAR T cells to other blood cancers, such as multiple myeloma and Hodgkin’s disease, as well as solid tumors of the breast, prostate, brain, lungs and other organs.

A Comprehensive Cancer Center

As part of the UCSF Helen Diller Family Comprehensive Cancer Center, we offer our patients access to many services, including support groups, exercise and mindfulness classes, psychosocial support, symptom management and much more. 

Parker Institute for Cancer Immunotherapy

Our program is a member of the Parker Institute for Cancer Immunotherapy, a consortium made up of 10 of the world’s leading cancer centers. Its mission is to turn cancer into a curable disease by accelerating the development of breakthrough immune therapies.

Our locations

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    Patient education

    Hematology and BMT Resource Guide

    This hematology and bone marrow transplant (BMT) resource guide provides information about diseases and treatments, employment, insurance and more.

    Autologous Transplant Guide

    Having a blood and marrow transplant (BMT) is a difficult experience. Read this guide to help prepare you and your family and book an appointment today.

    Matched Unrelated Donor Transplantation

    Bone marrow transplantation can be performed using one's own bone marrow or by using another person's bone marrow. Learn more here.

    Decorative Caduceus

    Gene Therapy in Treating Patients With Human Immunodeficiency Virus-Related Lymphoma Receiving ...

    Efficacy rates will be summarized by the proportion of participants who meet the criteria for efficacy, with 95% exact binomial CIs.

    Recruiting

    Decorative Caduceus

    Phase Ib Study of SAR650984 in Combination With Carfilzomib for Treatment of Relapsed or Refrac...

    Treatment-related Adverse events resulting in a DLT will be summarized by maximum toxicity grade for each dose level of isatuximab.

    Recruiting

    Decorative Caduceus

    Study of STRO-001, an Anti-CD74 Antibody Drug Conjugate, in Patients With Advanced B-Cell Malig...

    Incidence of adverse events (AEs) observed across STRO-001 dose levels

    Recruiting

    Decorative Caduceus

    Anti-CD19 Chimeric Antigen Receptor T Cells for Treatment of Relapsed or Refractory Non-Hodgkin...

    All subjects enrolled in this phase I study who actually received study drug (anti-CD19 CAR-T infusion) will be included in the analysis. Proportion of participants with treatment-emergent adverse events of CAR-T in B-cell NHL, as...

    Recruiting

    Decorative Caduceus

    Blinatumomab and Pembrolizumab for Adults With Relapsed/Refractory B-cell Acute Lymphoblastic L...

    Recruiting

    Decorative Caduceus

    Ibrutinib, Rituximab, Etoposide, Prednisone, Vincristine Sulfate, Cyclophosphamide, and Doxorub...

    There will be no formal statistical testing for the dose-finding portion of the study.

    Recruiting

    Decorative Caduceus

    CPX-351 and Gemtuzumab Ozogamicin in Treating Patients With Relapsed Acute Myeloid Leukemia

    MTD is defined as the cohort of participants one cohort below the cohort that develop dose-limiting toxicity (DLT) in at least 2 participants.

    Recruiting

    Decorative Caduceus

    Daratumumab, Azacitidine, and Dexamethasone for Treatment of Patients With Recurrent or Refract...

    ORR is defined as stringent complete response (sCR) + complete response (CR) + very good partial response + partial response (PR) as best response using International Myeloma Working Group (IMWG) Uniform Response Criteria for all ...

    Recruiting

    Decorative Caduceus

    A Study of Oral LOXO-305 in Patients With Previously Treated CLL/SLL or NHL

    Phase I

    Recruiting

    Decorative Caduceus

    Study of FF-10101-01 in Patients With Relapsed or Refractory Acute Myeloid Leukemia

    Safety Assessments include frequency of adverse events (AEs) in percentage (%)

    Recruiting

    Rankings & achievements

    • usnews-neurology

      Best hospital in Northern California

    • Best in Northern California in cancer care

    • 220-2x

      blood and marrow transplants performed each year

    • 1986-2x

      Founded in 1986

    Accreditations & memberships

    • National Cancer Institute

      The National Cancer Institute has designated UCSF a comprehensive cancer center, its highest ranking. This designation is awarded to centers that demonstrate scientific excellence and the ability to conduct cancer research across many disciplines.

    • Commission on Cancer

      UCSF's cancer programs have been accredited by the American College of Surgeons' Commission on Cancer (CoC) since 1933. The CoC is a consortium of groups dedicated to improving cancer patients' survival and quality of life via research, education and better medical care.

    • National Comprehensive Cancer Network

      UCSF is a founding member of the National Comprehensive Cancer Network, an alliance of the world’s top cancer centers. The network brings together leaders in treatment and research to improve the quality, effectiveness and efficiency of cancer care.

    Support services

    Patient Resource

    Case Management and Social Work

    Connect with a team that can help you find resources, solve problems and advocate for you during treatment at UCSF.

    Patient Resource

    Koz Hospitality House

    Located near our Parnassus campus, Koz Hospitality House provides comfortable, reasonably priced accommodations for UCSF patients during their treatment.

    Class

    Mindfulness-Based Stress Reduction Class

    This eight-week UCSF class teaches mindfulness practices, such as meditation and body awareness, that can reduce stress and improve your overall health.

    Patient Resource

    Patient Relations

    We welcome feedback about your experience at UCSF Health. Find out how to contact us with comments, questions or concerns.

    Patient Resource

    Spiritual Care Services

    Chaplains representing many faiths are available around the clock to provide support, comfort and counsel to patients, families and caregivers. Learn more.

    Preparing for your appointment

    What to Bring

    • Photo I.D.
    • Health insurance card
    • Insurance authorization, if required
    • Doctor's referral, if required
    • Recent test results related to your condition
    • List of your medications, including dosages, plus any you're allergic to
    • List of questions you may have
    • Device or paper for taking notes

    International Services

    If you live in another country and are coming to UCSF for medical
    treatment, our patient liaisons can help coordinate all aspects of your visit.

    Learn more

    Interpreters

    UCSF offers language services at no charge for patients with limited
    English, as well as for patients who are deaf or have trouble hearing.

    Learn more

    Hospital Stays

    Checking into the hospital? Find helpful information by clicking on the relevant “Your Hospital Stay” booklet: Mission Bay, Parnassus or Mount
    Zion.

    Learn more

    Your Doctor Visit

    See our top 10 tips for making your UCSF doctor’s appointment as stress-free and productive as possible.

    Learn more

    Related clinics

    Hemophilia Treatment Center

    400 Parnassus Ave., 4th Floor
    San Francisco, CA 94143

    Cancer Immunotherapy Clinic

    Bakar Precision Cancer Medicine Building

    1825 Fourth St., Fifth Floor
    San Francisco, CA 94158

    Cancer Symptom Management

    Bakar Precision Cancer Medicine Building

    1825 Fourth St.
    San Francisco, CA 94115

    Cancer Center San Mateo

    218 DeAnza Blvd.
    San Mateo, CA 94402

    Psycho-Oncology

    Bakar Precision Cancer Medicine Building

    1600 Divisadero St.
    San Francisco, CA 94115

    UCSF-John Muir Health Cancer Center in Berkeley

    Berkeley Outpatient Center

    3100 San Pablo Ave., Suite 430
    Berkeley, CA 94702

    Our research initiatives

    • UCSF-Helen-Diller-Family-Comprehensive-Cancer-Center-Research-2x

      UCSF Helen Diller Family Comprehensive Cancer Center Research

      UCSF is home to a range of research initiatives aimed at improving outcomes for cancer patients everywhere. This includes research on topics such as immunotherapy, BRCA mutations and molecular diagnostic testing.

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    UCSF Help Center

    (888) 689-8273

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